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RELATIONS BETWEEN ASTHMA AND OBESITY: AN ANALYSIS OF MULTIPLE FACTORS

OBJECTIVE: Asthma and obesity are prevalent and interrelated diseases. In the pediatric population, the effect of systemic inflammation associated to obesity, leading to inflammation of the airways, is currently controversial. Our aim was to compare inflammatory, clinical and spirometric patterns be...

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Autores principales: Madeira, Leticia Nabuco de Oliveira, Bordallo, Maria Alice Neves, Borges, Marcos Antonio, Lopes, Agnaldo José, Madeira, Isabel Rey, Kuschnir, Fábio Chigres
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade de Pediatria de São Paulo 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7649860/
https://www.ncbi.nlm.nih.gov/pubmed/33175004
http://dx.doi.org/10.1590/1984-0462/2021/39/2019405
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author Madeira, Leticia Nabuco de Oliveira
Bordallo, Maria Alice Neves
Borges, Marcos Antonio
Lopes, Agnaldo José
Madeira, Isabel Rey
Kuschnir, Fábio Chigres
author_facet Madeira, Leticia Nabuco de Oliveira
Bordallo, Maria Alice Neves
Borges, Marcos Antonio
Lopes, Agnaldo José
Madeira, Isabel Rey
Kuschnir, Fábio Chigres
author_sort Madeira, Leticia Nabuco de Oliveira
collection PubMed
description OBJECTIVE: Asthma and obesity are prevalent and interrelated diseases. In the pediatric population, the effect of systemic inflammation associated to obesity, leading to inflammation of the airways, is currently controversial. Our aim was to compare inflammatory, clinical and spirometric patterns between children with asthma and obesity and those within the normal weight status range. METHODS: A total of 79 boys and girls from 6 to 10 years old were selected and divided into four groups: obese asthmatics, non-obese asthmatics, obese non-asthmatics, and non-obese non-asthmatics. In addition to collecting clinical and anthropometric data, all children underwent spirometry and skin prick tests for inhalant allergens. Blood samples for measurement of cytokines and adipokines were also collected. RESULTS: Obese asthmatics had significantly worse control of asthma than non-obese asthmatics (OR 4.9; 95%CI 1.1‒22.1), regardless of sex, physical activity and atopy. No differences in spirometry, Th1 and Th2 cytokines and adipokines levels were observed among the four groups. The prick tests were positive in 81.8 and 80% of non-obese asthmatics and obese asthmatics, respectively. CONCLUSIONS: The degree of control of asthma was significantly lower in the obese group, regardless of the findings of no differences in spirometry. Extra-pulmonary factors could be responsible for this symptomatic profile. High positivity of skin test in both groups, which is considered a good marker of atopy, shows a preponderant atopic component in the genesis of asthma, both in children with obesity and in those within the normal weight status.
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spelling pubmed-76498602020-11-17 RELATIONS BETWEEN ASTHMA AND OBESITY: AN ANALYSIS OF MULTIPLE FACTORS Madeira, Leticia Nabuco de Oliveira Bordallo, Maria Alice Neves Borges, Marcos Antonio Lopes, Agnaldo José Madeira, Isabel Rey Kuschnir, Fábio Chigres Rev Paul Pediatr Original Article OBJECTIVE: Asthma and obesity are prevalent and interrelated diseases. In the pediatric population, the effect of systemic inflammation associated to obesity, leading to inflammation of the airways, is currently controversial. Our aim was to compare inflammatory, clinical and spirometric patterns between children with asthma and obesity and those within the normal weight status range. METHODS: A total of 79 boys and girls from 6 to 10 years old were selected and divided into four groups: obese asthmatics, non-obese asthmatics, obese non-asthmatics, and non-obese non-asthmatics. In addition to collecting clinical and anthropometric data, all children underwent spirometry and skin prick tests for inhalant allergens. Blood samples for measurement of cytokines and adipokines were also collected. RESULTS: Obese asthmatics had significantly worse control of asthma than non-obese asthmatics (OR 4.9; 95%CI 1.1‒22.1), regardless of sex, physical activity and atopy. No differences in spirometry, Th1 and Th2 cytokines and adipokines levels were observed among the four groups. The prick tests were positive in 81.8 and 80% of non-obese asthmatics and obese asthmatics, respectively. CONCLUSIONS: The degree of control of asthma was significantly lower in the obese group, regardless of the findings of no differences in spirometry. Extra-pulmonary factors could be responsible for this symptomatic profile. High positivity of skin test in both groups, which is considered a good marker of atopy, shows a preponderant atopic component in the genesis of asthma, both in children with obesity and in those within the normal weight status. Sociedade de Pediatria de São Paulo 2020-11-06 /pmc/articles/PMC7649860/ /pubmed/33175004 http://dx.doi.org/10.1590/1984-0462/2021/39/2019405 Text en https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License
spellingShingle Original Article
Madeira, Leticia Nabuco de Oliveira
Bordallo, Maria Alice Neves
Borges, Marcos Antonio
Lopes, Agnaldo José
Madeira, Isabel Rey
Kuschnir, Fábio Chigres
RELATIONS BETWEEN ASTHMA AND OBESITY: AN ANALYSIS OF MULTIPLE FACTORS
title RELATIONS BETWEEN ASTHMA AND OBESITY: AN ANALYSIS OF MULTIPLE FACTORS
title_full RELATIONS BETWEEN ASTHMA AND OBESITY: AN ANALYSIS OF MULTIPLE FACTORS
title_fullStr RELATIONS BETWEEN ASTHMA AND OBESITY: AN ANALYSIS OF MULTIPLE FACTORS
title_full_unstemmed RELATIONS BETWEEN ASTHMA AND OBESITY: AN ANALYSIS OF MULTIPLE FACTORS
title_short RELATIONS BETWEEN ASTHMA AND OBESITY: AN ANALYSIS OF MULTIPLE FACTORS
title_sort relations between asthma and obesity: an analysis of multiple factors
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7649860/
https://www.ncbi.nlm.nih.gov/pubmed/33175004
http://dx.doi.org/10.1590/1984-0462/2021/39/2019405
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