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CYP2D6 Predicts Plasma Donepezil Concentrations in a Cohort of Thai Patients with Mild to Moderate Dementia

PURPOSE: Donepezil, a drug frequently used to treat dementia, is mainly metabolized by cytochrome P450 2D6 (CYP2D6). This study investigated the relationships between CYP2D6 genotype and activity scores as well as predicted phenotype of plasma donepezil concentrations in 86 Thai dementia participant...

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Detalles Bibliográficos
Autores principales:	Chamnanphon, Monpat, Wainipitapong, Sorawit, Wiwattarangkul, Teeravut, Chuchuen, Phenphichcha, Nissaipan, Kunathip, Phaisal, Weeraya, Tangwongchai, Sookjaroen, Sukasem, Chonlaphat, Wittayalertpanya, Supeecha, Gaedigk, Andrea, Aniwattanapong, Daruj, Chariyavilaskul, Pajaree
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2020
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7649971/ https://www.ncbi.nlm.nih.gov/pubmed/33177862 http://dx.doi.org/10.2147/PGPM.S276230

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