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Long-Term Visual, Refractive and Topographic Outcomes of “Epi-off” Corneal Collagen Cross-Linking in Pediatric Keratoconus: Standard versus Accelerated Protocol
PURPOSE: To compare the visual, refractive and topographic outcomes of standard and accelerated corneal collagen cross-linking (CXL) in pediatric keratoconus patients. METHODS: Prospective, comparative observational study on 68 eyes of 35 pediatric keratoconus patients (<18 years). Patients were...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7650037/ https://www.ncbi.nlm.nih.gov/pubmed/33177802 http://dx.doi.org/10.2147/OPTH.S275797 |
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author | Amer, Ibrahim Elaskary, Abdelhakeem Mostafa, Ali Hazem, Hazem A Omar, Ahmed Abdou, Ahmed |
author_facet | Amer, Ibrahim Elaskary, Abdelhakeem Mostafa, Ali Hazem, Hazem A Omar, Ahmed Abdou, Ahmed |
author_sort | Amer, Ibrahim |
collection | PubMed |
description | PURPOSE: To compare the visual, refractive and topographic outcomes of standard and accelerated corneal collagen cross-linking (CXL) in pediatric keratoconus patients. METHODS: Prospective, comparative observational study on 68 eyes of 35 pediatric keratoconus patients (<18 years). Patients were classified into two groups, group (I) included 34 eyes and received standard “Epi-Off” CXL (3 mW/cm(2), 30 min.) and group (II) included 34 eyes and received accelerated “Epi-Off” CXL (9 mW/cm(2), 10 min.). Uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), spherical equivalent (SE), simulated keratometry (Sim K-1, Sim K-2, K-max, K-mean), cylindrical (CYL), pachymetry and Q-value were evaluated preoperatively and for 3 years postoperatively. RESULTS: Postoperative UDVA and CDVA did not significantly change in both groups after 3 years. Postoperative SE was increased significantly in accelerated CXL (p=0.012) with no significant change in the postoperative cylinder in both procedures. Standard CXL had greater “significant” effect in decreasing Sim K-1, K-max and K-mean. The mean reduction in postoperative corneal pachymetry (at thinnest location) was significant in standard CXL (18.4 μm) (p=0.001). No significant change was noticed in postoperative Q-value. CONCLUSION: Standard and accelerated CXL protocols are efficient in pediatric keratoconus management with better outcomes in the standard procedure. |
format | Online Article Text |
id | pubmed-7650037 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-76500372020-11-10 Long-Term Visual, Refractive and Topographic Outcomes of “Epi-off” Corneal Collagen Cross-Linking in Pediatric Keratoconus: Standard versus Accelerated Protocol Amer, Ibrahim Elaskary, Abdelhakeem Mostafa, Ali Hazem, Hazem A Omar, Ahmed Abdou, Ahmed Clin Ophthalmol Original Research PURPOSE: To compare the visual, refractive and topographic outcomes of standard and accelerated corneal collagen cross-linking (CXL) in pediatric keratoconus patients. METHODS: Prospective, comparative observational study on 68 eyes of 35 pediatric keratoconus patients (<18 years). Patients were classified into two groups, group (I) included 34 eyes and received standard “Epi-Off” CXL (3 mW/cm(2), 30 min.) and group (II) included 34 eyes and received accelerated “Epi-Off” CXL (9 mW/cm(2), 10 min.). Uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), spherical equivalent (SE), simulated keratometry (Sim K-1, Sim K-2, K-max, K-mean), cylindrical (CYL), pachymetry and Q-value were evaluated preoperatively and for 3 years postoperatively. RESULTS: Postoperative UDVA and CDVA did not significantly change in both groups after 3 years. Postoperative SE was increased significantly in accelerated CXL (p=0.012) with no significant change in the postoperative cylinder in both procedures. Standard CXL had greater “significant” effect in decreasing Sim K-1, K-max and K-mean. The mean reduction in postoperative corneal pachymetry (at thinnest location) was significant in standard CXL (18.4 μm) (p=0.001). No significant change was noticed in postoperative Q-value. CONCLUSION: Standard and accelerated CXL protocols are efficient in pediatric keratoconus management with better outcomes in the standard procedure. Dove 2020-11-03 /pmc/articles/PMC7650037/ /pubmed/33177802 http://dx.doi.org/10.2147/OPTH.S275797 Text en © 2020 Amer et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Original Research Amer, Ibrahim Elaskary, Abdelhakeem Mostafa, Ali Hazem, Hazem A Omar, Ahmed Abdou, Ahmed Long-Term Visual, Refractive and Topographic Outcomes of “Epi-off” Corneal Collagen Cross-Linking in Pediatric Keratoconus: Standard versus Accelerated Protocol |
title | Long-Term Visual, Refractive and Topographic Outcomes of “Epi-off” Corneal Collagen Cross-Linking in Pediatric Keratoconus: Standard versus Accelerated Protocol |
title_full | Long-Term Visual, Refractive and Topographic Outcomes of “Epi-off” Corneal Collagen Cross-Linking in Pediatric Keratoconus: Standard versus Accelerated Protocol |
title_fullStr | Long-Term Visual, Refractive and Topographic Outcomes of “Epi-off” Corneal Collagen Cross-Linking in Pediatric Keratoconus: Standard versus Accelerated Protocol |
title_full_unstemmed | Long-Term Visual, Refractive and Topographic Outcomes of “Epi-off” Corneal Collagen Cross-Linking in Pediatric Keratoconus: Standard versus Accelerated Protocol |
title_short | Long-Term Visual, Refractive and Topographic Outcomes of “Epi-off” Corneal Collagen Cross-Linking in Pediatric Keratoconus: Standard versus Accelerated Protocol |
title_sort | long-term visual, refractive and topographic outcomes of “epi-off” corneal collagen cross-linking in pediatric keratoconus: standard versus accelerated protocol |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7650037/ https://www.ncbi.nlm.nih.gov/pubmed/33177802 http://dx.doi.org/10.2147/OPTH.S275797 |
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