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Sphingosine prevents binding of SARS–CoV-2 spike to its cellular receptor ACE2

Sphingosine has been shown to prevent and eliminate bacterial infections of the respiratory tract, but it is unknown whether sphingosine can be also employed to prevent viral infections. To test this hypothesis, we analyzed whether sphingosine regulates the infection of cultured and freshly isolated...

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Detalles Bibliográficos
Autores principales:	Edwards, Michael J., Becker, Katrin Anne, Gripp, Barbara, Hoffmann, Markus, Keitsch, Simone, Wilker, Barbara, Soddemann, Matthias, Gulbins, Anne, Carpinteiro, Elisa, Patel, Sameer H., Wilson, Gregory C., Pöhlmann, Stefan, Walter, Silke, Fassbender, Klaus, Ahmad, Syed A., Carpinteiro, Alexander, Gulbins, Erich
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2020
Materias:	Editors' Picks
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7650243/ https://www.ncbi.nlm.nih.gov/pubmed/32917722 http://dx.doi.org/10.1074/jbc.RA120.015249

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