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Inducible intracellular membranes: molecular aspects and emerging applications
Membrane remodeling and phospholipid biosynthesis are normally tightly regulated to maintain the shape and function of cells. Indeed, different physiological mechanisms ensure a precise coordination between de novo phospholipid biosynthesis and modulation of membrane morphology. Interestingly, the o...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7650269/ https://www.ncbi.nlm.nih.gov/pubmed/32887610 http://dx.doi.org/10.1186/s12934-020-01433-x |
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author | Royes, Jorge Biou, Valérie Dautin, Nathalie Tribet, Christophe Miroux, Bruno |
author_facet | Royes, Jorge Biou, Valérie Dautin, Nathalie Tribet, Christophe Miroux, Bruno |
author_sort | Royes, Jorge |
collection | PubMed |
description | Membrane remodeling and phospholipid biosynthesis are normally tightly regulated to maintain the shape and function of cells. Indeed, different physiological mechanisms ensure a precise coordination between de novo phospholipid biosynthesis and modulation of membrane morphology. Interestingly, the overproduction of certain membrane proteins hijack these regulation networks, leading to the formation of impressive intracellular membrane structures in both prokaryotic and eukaryotic cells. The proteins triggering an abnormal accumulation of membrane structures inside the cells (or membrane proliferation) share two major common features: (1) they promote the formation of highly curved membrane domains and (2) they lead to an enrichment in anionic, cone-shaped phospholipids (cardiolipin or phosphatidic acid) in the newly formed membranes. Taking into account the available examples of membrane proliferation upon protein overproduction, together with the latest biochemical, biophysical and structural data, we explore the relationship between protein synthesis and membrane biogenesis. We propose a mechanism for the formation of these non-physiological intracellular membranes that shares similarities with natural inner membrane structures found in α-proteobacteria, mitochondria and some viruses-infected cells, pointing towards a conserved feature through evolution. We hope that the information discussed in this review will give a better grasp of the biophysical mechanisms behind physiological and induced intracellular membrane proliferation, and inspire new applications, either for academia (high-yield membrane protein production and nanovesicle production) or industry (biofuel production and vaccine preparation). |
format | Online Article Text |
id | pubmed-7650269 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-76502692020-11-09 Inducible intracellular membranes: molecular aspects and emerging applications Royes, Jorge Biou, Valérie Dautin, Nathalie Tribet, Christophe Miroux, Bruno Microb Cell Fact Review Membrane remodeling and phospholipid biosynthesis are normally tightly regulated to maintain the shape and function of cells. Indeed, different physiological mechanisms ensure a precise coordination between de novo phospholipid biosynthesis and modulation of membrane morphology. Interestingly, the overproduction of certain membrane proteins hijack these regulation networks, leading to the formation of impressive intracellular membrane structures in both prokaryotic and eukaryotic cells. The proteins triggering an abnormal accumulation of membrane structures inside the cells (or membrane proliferation) share two major common features: (1) they promote the formation of highly curved membrane domains and (2) they lead to an enrichment in anionic, cone-shaped phospholipids (cardiolipin or phosphatidic acid) in the newly formed membranes. Taking into account the available examples of membrane proliferation upon protein overproduction, together with the latest biochemical, biophysical and structural data, we explore the relationship between protein synthesis and membrane biogenesis. We propose a mechanism for the formation of these non-physiological intracellular membranes that shares similarities with natural inner membrane structures found in α-proteobacteria, mitochondria and some viruses-infected cells, pointing towards a conserved feature through evolution. We hope that the information discussed in this review will give a better grasp of the biophysical mechanisms behind physiological and induced intracellular membrane proliferation, and inspire new applications, either for academia (high-yield membrane protein production and nanovesicle production) or industry (biofuel production and vaccine preparation). BioMed Central 2020-09-04 /pmc/articles/PMC7650269/ /pubmed/32887610 http://dx.doi.org/10.1186/s12934-020-01433-x Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Review Royes, Jorge Biou, Valérie Dautin, Nathalie Tribet, Christophe Miroux, Bruno Inducible intracellular membranes: molecular aspects and emerging applications |
title | Inducible intracellular membranes: molecular aspects and emerging applications |
title_full | Inducible intracellular membranes: molecular aspects and emerging applications |
title_fullStr | Inducible intracellular membranes: molecular aspects and emerging applications |
title_full_unstemmed | Inducible intracellular membranes: molecular aspects and emerging applications |
title_short | Inducible intracellular membranes: molecular aspects and emerging applications |
title_sort | inducible intracellular membranes: molecular aspects and emerging applications |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7650269/ https://www.ncbi.nlm.nih.gov/pubmed/32887610 http://dx.doi.org/10.1186/s12934-020-01433-x |
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