Cargando…

Evolutionary Study of Disorder in Protein Sequences

Intrinsically disordered proteins (IDPs) contain regions lacking intrinsic globular structure (intrinsically disordered regions, IDRs). IDPs are present across the tree of life, with great variability of IDR type and frequency even between closely related taxa. To investigate the function of IDRs, w...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kastano, Kristina, Erdős, Gábor, Mier, Pablo, Alanis-Lobato, Gregorio, Promponas, Vasilis J., Dosztányi, Zsuzsanna, Andrade-Navarro, Miguel A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7650552/ https://www.ncbi.nlm.nih.gov/pubmed/33036302 http://dx.doi.org/10.3390/biom10101413

Ejemplares similares

Functional Tuning of Intrinsically Disordered Regions in Human Proteins by Composition Bias
por: Kastano, Kristina, et al.
Publicado: (2022)

IUPred3: prediction of protein disorder enhanced with unambiguous experimental annotation and visualization of evolutionary conservation
por: Erdős, Gábor, et al.
Publicado: (2021)

The latent geometry of the human protein interaction network
por: Alanis-Lobato, Gregorio, et al.
Publicado: (2018)

The Role of Low Complexity Regions in Protein Interaction Modes: An Illustration in Huntingtin
por: Kastano, Kristina, et al.
Publicado: (2021)

The Origin of Discrepancies between Predictions and Annotations in Intrinsically Disordered Proteins
por: Pajkos, Mátyás, et al.
Publicado: (2023)

IUPred2A: context-dependent prediction of protein disorder as a function of redox state and protein binding
por: Mészáros, Bálint, et al.
Publicado: (2018)

Manifold learning and maximum likelihood estimation for hyperbolic network embedding
por: Alanis-Lobato, Gregorio, et al.
Publicado: (2016)

Efficient embedding of complex networks to hyperbolic space via their Laplacian
por: Alanis-Lobato, Gregorio, et al.
Publicado: (2016)

Low Complexity Induces Structure in Protein Regions Predicted as Intrinsically Disordered
por: Gonçalves-Kulik, Mariane, et al.
Publicado: (2022)

DisCanVis: Visualizing integrated structural and functional annotations to better understand the effect of cancer mutations located within disordered proteins
por: Deutsch, Norbert, et al.
Publicado: (2023)

Evolutionary Study of Protein Short Tandem Repeats in Protein Families
por: Mier, Pablo, et al.
Publicado: (2023)

PlaToLoCo: the first web meta-server for visualization and annotation of low complexity regions in proteins
por: Jarnot, Patryk, et al.
Publicado: (2020)

The MemMoRF database for recognizing disordered protein regions interacting with cellular membranes
por: Csizmadia, Georgina, et al.
Publicado: (2020)

HIPPIE v2.0: enhancing meaningfulness and reliability of protein–protein interaction networks
por: Alanis-Lobato, Gregorio, et al.
Publicado: (2017)

Ancient Evolutionary Origin of Intrinsically Disordered Cancer Risk Regions
por: Pajkos, Mátyás, et al.
Publicado: (2020)

Disentangling the complexity of low complexity proteins
por: Mier, Pablo, et al.
Publicado: (2019)

MIPPIE: the mouse integrated protein–protein interaction reference
por: Alanis-Lobato, Gregorio, et al.
Publicado: (2020)

Automated selection of homologs to track the evolutionary history of proteins
por: Mier, Pablo, et al.
Publicado: (2018)

The features of polyglutamine regions depend on their evolutionary stability
por: Mier, Pablo, et al.
Publicado: (2020)

CellMap visualizes protein-protein interactions and subcellular localization
por: Dallago, Christian, et al.
Publicado: (2018)

Tandem repeats lead to sequence assembly errors and impose multi-level challenges for genome and protein databases
por: Tørresen, Ole K, et al.
Publicado: (2019)

Geometric characterisation of disease modules
por: Härtner, Franziska, et al.
Publicado: (2018)

Assessing the low complexity of protein sequences via the low complexity triangle
por: Mier, Pablo, et al.
Publicado: (2020)

Prediction of Protein Binding Regions in Disordered Proteins
por: Mészáros, Bálint, et al.
Publicado: (2009)

Regions with two amino acids in protein sequences: A step forward from homorepeats into the low complexity landscape
por: Mier, Pablo, et al.
Publicado: (2022)

Assessing the reliability of gene expression measurements in very-low-numbers of human monocyte-derived macrophages
por: Geiß, Carsten, et al.
Publicado: (2019)

ANCHOR: web server for predicting protein binding regions in disordered proteins
por: Dosztányi, Zsuzsanna, et al.
Publicado: (2009)

PDB_TM: selection and membrane localization of transmembrane proteins in the protein data bank
por: Tusnády, Gábor E., et al.
Publicado: (2005)

Mining protein interactomes to improve their reliability and support the advancement of network medicine
por: Alanis-Lobato, Gregorio
Publicado: (2015)

Phase separating Rho: a widespread regulatory function of disordered regions in proteins revealed in bacteria
por: Schumbera, Eric, et al.
Publicado: (2023)

LCR-eXXXplorer: a web platform to search, visualize and share data for low complexity regions in protein sequences
por: Kirmitzoglou, Ioannis, et al.
Publicado: (2015)

Novel linear motif filtering protocol reveals the role of the LC8 dynein light chain in the Hippo pathway
por: Erdős, Gábor, et al.
Publicado: (2017)

The Conservation of Low Complexity Regions in Bacterial Proteins Depends on the Pathogenicity of the Strain and Subcellular Location of the Protein
por: Mier, Pablo, et al.
Publicado: (2021)

Detection of condition-specific marker genes from RNA-seq data with MGFR
por: El Amrani, Khadija, et al.
Publicado: (2019)

PolyX2: Fast Detection of Homorepeats in Large Protein Datasets
por: Mier, Pablo, et al.
Publicado: (2022)

The interaction between LC8 and LCA5 reveals a novel oligomerization function of LC8 in the ciliary-centrosome system
por: Szaniszló, Tamás, et al.
Publicado: (2022)

Mutations of Intrinsically Disordered Protein Regions Can Drive Cancer but Lack Therapeutic Strategies
por: Mészáros, Bálint, et al.
Publicado: (2021)

The Protein Structure Context of PolyQ Regions
por: Totzeck, Franziska, et al.
Publicado: (2017)

Interaction profiling of RNA-binding ubiquitin ligases reveals a link between posttranscriptional regulation and the ubiquitin system
por: Hildebrandt, Andrea, et al.
Publicado: (2017)

Minimum curvilinearity to enhance topological prediction of protein interactions by network embedding
por: Cannistraci, Carlo Vittorio, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_ahck75ftghcjr3omnh9ogo9qq3