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Association of Hypertension with All-Cause Mortality among Hospitalized Patients with COVID-19

It is unclear to which extent the higher mortality associated with hypertension in the coronavirus disease (COVID-19) is due to its increased prevalence among older patients or to specific mechanisms. Cross-sectional, observational, retrospective multicenter study, analyzing 12226 patients who requi...

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Autores principales: Rodilla, Enrique, Saura, Alberto, Jiménez, Iratxe, Mendizábal, Andrea, Pineda-Cantero, Araceli, Lorenzo-Hernández, Elizabeth, Fidalgo-Montero, Maria del Pilar, López-Cuervo, Joaquín Fernandez, Gil-Sánchez, Ricardo, Rabadán-Pejenaute, Elisa, Abella-Vázquez, Lucy, Giner-Galvañ, Vicente, Solís-Marquínez, Marta Nataya, Boixeda, Ramon, de la Peña-Fernández, Andrés, Carrasco-Sánchez, Francisco Javier, González-Moraleja, Julio, Torres-Peña, José David, Guisado-Espartero, María Esther, Escobar-Sevilla, Joaquín, Guzmán-García, Marcos, Martín-Escalante, María Dolores, Martínez-González, Ángel Luis, Casas-Rojo, José Manuel, Gómez-Huelgas, Ricardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7650567/
https://www.ncbi.nlm.nih.gov/pubmed/32998337
http://dx.doi.org/10.3390/jcm9103136
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author Rodilla, Enrique
Saura, Alberto
Jiménez, Iratxe
Mendizábal, Andrea
Pineda-Cantero, Araceli
Lorenzo-Hernández, Elizabeth
Fidalgo-Montero, Maria del Pilar
López-Cuervo, Joaquín Fernandez
Gil-Sánchez, Ricardo
Rabadán-Pejenaute, Elisa
Abella-Vázquez, Lucy
Giner-Galvañ, Vicente
Solís-Marquínez, Marta Nataya
Boixeda, Ramon
de la Peña-Fernández, Andrés
Carrasco-Sánchez, Francisco Javier
González-Moraleja, Julio
Torres-Peña, José David
Guisado-Espartero, María Esther
Escobar-Sevilla, Joaquín
Guzmán-García, Marcos
Martín-Escalante, María Dolores
Martínez-González, Ángel Luis
Casas-Rojo, José Manuel
Gómez-Huelgas, Ricardo
author_facet Rodilla, Enrique
Saura, Alberto
Jiménez, Iratxe
Mendizábal, Andrea
Pineda-Cantero, Araceli
Lorenzo-Hernández, Elizabeth
Fidalgo-Montero, Maria del Pilar
López-Cuervo, Joaquín Fernandez
Gil-Sánchez, Ricardo
Rabadán-Pejenaute, Elisa
Abella-Vázquez, Lucy
Giner-Galvañ, Vicente
Solís-Marquínez, Marta Nataya
Boixeda, Ramon
de la Peña-Fernández, Andrés
Carrasco-Sánchez, Francisco Javier
González-Moraleja, Julio
Torres-Peña, José David
Guisado-Espartero, María Esther
Escobar-Sevilla, Joaquín
Guzmán-García, Marcos
Martín-Escalante, María Dolores
Martínez-González, Ángel Luis
Casas-Rojo, José Manuel
Gómez-Huelgas, Ricardo
author_sort Rodilla, Enrique
collection PubMed
description It is unclear to which extent the higher mortality associated with hypertension in the coronavirus disease (COVID-19) is due to its increased prevalence among older patients or to specific mechanisms. Cross-sectional, observational, retrospective multicenter study, analyzing 12226 patients who required hospital admission in 150 Spanish centers included in the nationwide SEMI-COVID-19 Network. We compared the clinical characteristics of survivors versus non-survivors. The mean age of the study population was 67.5 ± 16.1 years, 42.6% were women. Overall, 2630 (21.5%) subjects died. The most common comorbidity was hypertension (50.9%) followed by diabetes (19.1%), and atrial fibrillation (11.2%). Multivariate analysis showed that after adjusting for gender (males, OR: 1.5, p = 0.0001), age tertiles (second and third tertiles, OR: 2.0 and 4.7, p = 0.0001), and Charlson Comorbidity Index scores (second and third tertiles, OR: 4.7 and 8.1, p = 0.0001), hypertension was significantly predictive of all-cause mortality when this comorbidity was treated with angiotensin-converting enzyme inhibitors (ACEIs) (OR: 1.6, p = 0.002) or other than renin-angiotensin-aldosterone blockers (OR: 1.3, p = 0.001) or angiotensin II receptor blockers (ARBs) (OR: 1.2, p = 0.035). The preexisting condition of hypertension had an independent prognostic value for all-cause mortality in patients with COVID-19 who required hospitalization. ARBs showed a lower risk of lethality in hypertensive patients than other antihypertensive drugs.
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spelling pubmed-76505672020-11-10 Association of Hypertension with All-Cause Mortality among Hospitalized Patients with COVID-19 Rodilla, Enrique Saura, Alberto Jiménez, Iratxe Mendizábal, Andrea Pineda-Cantero, Araceli Lorenzo-Hernández, Elizabeth Fidalgo-Montero, Maria del Pilar López-Cuervo, Joaquín Fernandez Gil-Sánchez, Ricardo Rabadán-Pejenaute, Elisa Abella-Vázquez, Lucy Giner-Galvañ, Vicente Solís-Marquínez, Marta Nataya Boixeda, Ramon de la Peña-Fernández, Andrés Carrasco-Sánchez, Francisco Javier González-Moraleja, Julio Torres-Peña, José David Guisado-Espartero, María Esther Escobar-Sevilla, Joaquín Guzmán-García, Marcos Martín-Escalante, María Dolores Martínez-González, Ángel Luis Casas-Rojo, José Manuel Gómez-Huelgas, Ricardo J Clin Med Article It is unclear to which extent the higher mortality associated with hypertension in the coronavirus disease (COVID-19) is due to its increased prevalence among older patients or to specific mechanisms. Cross-sectional, observational, retrospective multicenter study, analyzing 12226 patients who required hospital admission in 150 Spanish centers included in the nationwide SEMI-COVID-19 Network. We compared the clinical characteristics of survivors versus non-survivors. The mean age of the study population was 67.5 ± 16.1 years, 42.6% were women. Overall, 2630 (21.5%) subjects died. The most common comorbidity was hypertension (50.9%) followed by diabetes (19.1%), and atrial fibrillation (11.2%). Multivariate analysis showed that after adjusting for gender (males, OR: 1.5, p = 0.0001), age tertiles (second and third tertiles, OR: 2.0 and 4.7, p = 0.0001), and Charlson Comorbidity Index scores (second and third tertiles, OR: 4.7 and 8.1, p = 0.0001), hypertension was significantly predictive of all-cause mortality when this comorbidity was treated with angiotensin-converting enzyme inhibitors (ACEIs) (OR: 1.6, p = 0.002) or other than renin-angiotensin-aldosterone blockers (OR: 1.3, p = 0.001) or angiotensin II receptor blockers (ARBs) (OR: 1.2, p = 0.035). The preexisting condition of hypertension had an independent prognostic value for all-cause mortality in patients with COVID-19 who required hospitalization. ARBs showed a lower risk of lethality in hypertensive patients than other antihypertensive drugs. MDPI 2020-09-28 /pmc/articles/PMC7650567/ /pubmed/32998337 http://dx.doi.org/10.3390/jcm9103136 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Rodilla, Enrique
Saura, Alberto
Jiménez, Iratxe
Mendizábal, Andrea
Pineda-Cantero, Araceli
Lorenzo-Hernández, Elizabeth
Fidalgo-Montero, Maria del Pilar
López-Cuervo, Joaquín Fernandez
Gil-Sánchez, Ricardo
Rabadán-Pejenaute, Elisa
Abella-Vázquez, Lucy
Giner-Galvañ, Vicente
Solís-Marquínez, Marta Nataya
Boixeda, Ramon
de la Peña-Fernández, Andrés
Carrasco-Sánchez, Francisco Javier
González-Moraleja, Julio
Torres-Peña, José David
Guisado-Espartero, María Esther
Escobar-Sevilla, Joaquín
Guzmán-García, Marcos
Martín-Escalante, María Dolores
Martínez-González, Ángel Luis
Casas-Rojo, José Manuel
Gómez-Huelgas, Ricardo
Association of Hypertension with All-Cause Mortality among Hospitalized Patients with COVID-19
title Association of Hypertension with All-Cause Mortality among Hospitalized Patients with COVID-19
title_full Association of Hypertension with All-Cause Mortality among Hospitalized Patients with COVID-19
title_fullStr Association of Hypertension with All-Cause Mortality among Hospitalized Patients with COVID-19
title_full_unstemmed Association of Hypertension with All-Cause Mortality among Hospitalized Patients with COVID-19
title_short Association of Hypertension with All-Cause Mortality among Hospitalized Patients with COVID-19
title_sort association of hypertension with all-cause mortality among hospitalized patients with covid-19
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7650567/
https://www.ncbi.nlm.nih.gov/pubmed/32998337
http://dx.doi.org/10.3390/jcm9103136
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