Dynasore Blocks Ferroptosis through Combined Modulation of Iron Uptake and Inhibition of Mitochondrial Respiration

Ferroptosis is a form of regulated necrosis characterized by a chain-reaction of detrimental membrane lipid peroxidation following collapse of glutathione peroxidase 4 (Gpx4) activity. This lipid peroxidation is catalyzed by labile ferric iron. Therefore, iron import mediated via transferrin recepto...

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Detalles Bibliográficos
Autores principales: Clemente, Laura Prieto, Rabenau, Malena, Tang, Stephan, Stanka, Josefina, Cors, Eileen, Stroh, Jenny, Culmsee, Carsten, von Karstedt, Silvia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7650611/
https://www.ncbi.nlm.nih.gov/pubmed/33050207
http://dx.doi.org/10.3390/cells9102259

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