Cargando…

Penetration into Cancer Cells via Clathrin-Dependent Mechanism Allows L-Asparaginase from Rhodospirillum rubrum to Inhibit Telomerase

The anticancer effect of L-asparaginases (L-ASNases) is attributable to their ability to hydrolyze L-asparagine in the bloodstream and cancer cell microenvironment. Rhodospirillum rubrum (RrA) has dual mechanism of action and plays a role in the suppression of telomerase activity. The aim of this wo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Plyasova, Anna A., Pokrovskaya, Marina V., Lisitsyna, Olga M., Pokrovsky, Vadim S., Alexandrova, Svetlana S., Hilal, Abdullah, Sokolov, Nikolay N., Zhdanov, Dmitry D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7650658/ https://www.ncbi.nlm.nih.gov/pubmed/33008089 http://dx.doi.org/10.3390/ph13100286

Ejemplares similares

Inhibition of telomerase activity and induction of apoptosis by Rhodospirillum rubrum l‐asparaginase in cancer Jurkat cell line and normal human CD4+ T lymphocytes
por: Zhdanov, Dmitry D., et al.
Publicado: (2017)

Improvement of Biocatalytic Properties and Cytotoxic Activity of L-Asparaginase from Rhodospirillum rubrum by Conjugation with Chitosan-Based Cationic Polyelectrolytes
por: Dobryakova, Natalia V., et al.
Publicado: (2022)

Molecular Analysis of L-Asparaginases for Clarification of the Mechanism of Action and Optimization of Pharmacological Functions
por: Pokrovskaya, Marina V., et al.
Publicado: (2022)

The Structure of Rhodospirillum rubrum
por: Hickman, Donald D., et al.
Publicado: (1959)

THE FINE STRUCTURE OF RHODOSPIRILLUM RUBRUM
por: Cohen-Bazire, Germaine, et al.
Publicado: (1963)

OBSERVATIONS ON THE STRUCTURE OF RHODOSPIRILLUM RUBRUM
por: Hickman, Donald D., et al.
Publicado: (1965)

OBSERVATIONS ON THE FINE STRUCTURE OF SPHEROPLASTS OF RHODOSPIRILLUM RUBRUM
por: Boatman, E. S.
Publicado: (1964)

Highly Active Thermophilic L-Asparaginase from Melioribacter roseus Represents a Novel Large Group of Type II Bacterial L-Asparaginases from Chlorobi-Ignavibacteriae-Bacteroidetes Clade
por: Dumina, Maria, et al.
Publicado: (2021)

A Novel L-Asparaginase from Hyperthermophilic Archaeon Thermococcus sibiricus: Heterologous Expression and Characterization for Biotechnology Application
por: Dumina, Maria, et al.
Publicado: (2021)

Complete genome sequence of Rhodospirillum rubrum type strain (S1(T))
por: Munk, A. Christine, et al.
Publicado: (2011)

Temperature dependence of photosynthetic reaction centre activity in Rhodospirillum rubrum
por: Kaftan, David, et al.
Publicado: (2019)

Comparative immunogenicity and structural analysis of epitopes of different bacterial L-asparaginases
por: Pokrovsky, Vadim S., et al.
Publicado: (2016)

Structure and Photochemical Activity of Chlorophyll-Containing Particles from Rhodospirillum rubrum
por: Frenkel, Albert W., et al.
Publicado: (1959)

Investigation of candidate genes involved in the rhodoquinone biosynthetic pathway in Rhodospirillum rubrum
por: Campbell, Amanda R. M., et al.
Publicado: (2019)

Analysis of the Involvement of the Isoleucine Biosynthesis Pathway in Photoheterotrophic Metabolism of Rhodospirillum rubrum
por: Bayon-Vicente, Guillaume, et al.
Publicado: (2021)

Metabolic Regulation as a Consequence of Anaerobic 5-Methylthioadenosine Recycling in Rhodospirillum rubrum
por: North, Justin A., et al.
Publicado: (2016)

Alternative Splicing of Human Telomerase Reverse Transcriptase (hTERT) and Its Implications in Physiological and Pathological Processes
por: Plyasova, Anna A., et al.
Publicado: (2021)

Syngas obtained by microwave pyrolysis of household wastes as feedstock for polyhydroxyalkanoate production in Rhodospirillum rubrum
por: Revelles, Olga, et al.
Publicado: (2016)

Application of static and impulse magnetic fields to bacteria Rhodospirillum rubrum VKM B-1621
por: Khokhlova, Galina, et al.
Publicado: (2017)

New perspectives on butyrate assimilation in Rhodospirillum rubrum S1H under photoheterotrophic conditions
por: De Meur, Quentin, et al.
Publicado: (2020)

Cryo-EM structure of the Rhodospirillum rubrum RC–LH1 complex at 2.5 Å
por: Qian, Pu, et al.
Publicado: (2021)

Quorum sensing influences growth and photosynthetic membrane production in high-cell-density cultivations of Rhodospirillum rubrum
por: Carius, Lisa, et al.
Publicado: (2013)

Energy shifts induce membrane sequestration of DraG in Rhodospirillum rubrum independent of the ammonium transporters and diazotrophic conditions
por: Wang, Helen, et al.
Publicado: (2018)

Tailor‐made PAT platform for safe syngas fermentations in batch, fed‐batch and chemostat mode with Rhodospirillum rubrum
por: Karmann, Stephanie, et al.
Publicado: (2017)

Enhancement of biohydrogen production rate in Rhodospirillum rubrum by a dynamic CO-feeding strategy using dark fermentation
por: Rodríguez, Alberto, et al.
Publicado: (2021)

Effects of Mixing Volatile Fatty Acids as Carbon Sources on Rhodospirillum rubrum Carbon Metabolism and Redox Balance Mechanisms
por: Cabecas Segura, Paloma, et al.
Publicado: (2021)

Enhancing the Catalytic Activity of Thermo-Asparaginase from Thermococcus sibiricus by a Double Mesophilic-like Mutation in the Substrate-Binding Region
por: Dumina, Maria, et al.
Publicado: (2023)

Molecular basis for the distinct divalent cation requirement in the uridylylation of the signal transduction proteins GlnJ and GlnB from Rhodospirillum rubrum
por: Teixeira, Pedro Filipe, et al.
Publicado: (2012)

Global Proteomic Analysis Reveals High Light Intensity Adaptation Strategies and Polyhydroxyalkanoate Production in Rhodospirillum rubrum Cultivated With Acetate as Carbon Source
por: Bayon-Vicente, Guillaume, et al.
Publicado: (2020)

H(+)-Translocating Membrane-Bound Pyrophosphatase from Rhodospirillum rubrum Fuels Escherichia coli Cells via an Alternative Pathway for Energy Generation
por: Malykh, Evgeniya A., et al.
Publicado: (2023)

Aerobic-anaerobic transition boosts poly(3-hydroxybutyrate-co-3-hydroxyvalerate) synthesis in Rhodospirillum rubrum: the key role of carbon dioxide
por: Godoy, Manuel S., et al.
Publicado: (2023)

THE PHOTOSYNTHETIC APPARATUS OF RHODOSPIRILLUM MOLISCHIANUM
por: Gibbs, Sarah P., et al.
Publicado: (1965)

OBSERVATIONS ON THE STRUCTURE OF RHODOSPIRILLUM MOLISCHIANUM
por: Hickman, Donald D., et al.
Publicado: (1965)

Fed-Batch Cultivations of Rhodospirillum rubrum Under Multiple Nutrient-Limited Growth Conditions on Syngas as a Novel Option to Produce Poly(3-Hydroxybutyrate) (PHB)
por: Karmann, Stephanie, et al.
Publicado: (2019)

Engineering and Expression Strategies for Optimization of L-Asparaginase Development and Production
por: Shishparenok, Anastasiya N., et al.
Publicado: (2023)

Inactivation of clathrin heavy chain inhibits synaptic recycling but allows bulk membrane uptake
por: Kasprowicz, Jaroslaw, et al.
Publicado: (2008)

Telomerase Allows Human Preosteoblasts to Maintain Their Phenotype during the Immortalization Process
por: Darimont, Christian, et al.
Publicado: (2001)

Metabolic flexibility revealed in the genome of the cyst-forming α-1 proteobacterium Rhodospirillum centenum
por: Lu, Yih-Kuang, et al.
Publicado: (2010)

No Light, No Germination: Excitation of the Rhodospirillum centenum Photosynthetic Apparatus Is Necessary and Sufficient for Cyst Germination
por: Ashok, Nandhini, et al.
Publicado: (2021)

Tropomyosin-like properties of clathrin light chains allow a rapid, high-yield purification
Publicado: (1983)

Cannot write session to /tmp/vufind_sessions/sess_q072trrrp8n3u8tidlpvkmgg9m