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LPS-Induced Endotoxemia Evokes Epigenetic Alterations in Mitochondrial DNA That Impacts Inflammatory Response

Mitochondrial DNA (mtDNA) plays a vital role as a damage-associated molecular pattern in sepsis being able to shape the immune response. Since pathogen recognition receptors of innate immune cells are activated by demethylated DNA only, we set out to investigate the amount of DNA methyltransferase 1...

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Detalles Bibliográficos
Autores principales:	Koos, Björn, Moderegger, Eva Lotta, Rump, Katharina, Nowak, Hartmuth, Willemsen, Katrin, Holtkamp, Caroline, Thon, Patrick, Adamzik, Michael, Rahmel, Tim
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7650703/ https://www.ncbi.nlm.nih.gov/pubmed/33066217 http://dx.doi.org/10.3390/cells9102282

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