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Network Controllability-Based Prioritization of Candidates for SARS-CoV-2 Drug Repositioning
In a short time, the COVID-19 pandemic has left the world with over 25 million cases and staggering death tolls that are still rising. Treatments for SARS-CoV-2 infection are desperately needed as there are currently no approved drug therapies. With limited knowledge of viral mechanisms, a network c...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7650805/ https://www.ncbi.nlm.nih.gov/pubmed/32993136 http://dx.doi.org/10.3390/v12101087 |
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author | Ackerman, Emily E. Shoemaker, Jason E. |
author_facet | Ackerman, Emily E. Shoemaker, Jason E. |
author_sort | Ackerman, Emily E. |
collection | PubMed |
description | In a short time, the COVID-19 pandemic has left the world with over 25 million cases and staggering death tolls that are still rising. Treatments for SARS-CoV-2 infection are desperately needed as there are currently no approved drug therapies. With limited knowledge of viral mechanisms, a network controllability method of prioritizing existing drugs for repurposing efforts is optimal for quickly moving through the drug approval pipeline using limited, available, virus-specific data. Based on network topology and controllability, 16 proteins involved in translation, cellular transport, cellular stress, and host immune response are predicted as regulators of the SARS-CoV-2 infected cell. Of the 16, eight are prioritized as possible drug targets where two, PVR and SCARB1, are previously unexplored. Known compounds targeting these genes are suggested for viral inhibition study. Prioritized proteins in agreement with previous analysis and viral inhibition studies verify the ability of network controllability to predict biologically relevant candidates. |
format | Online Article Text |
id | pubmed-7650805 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-76508052020-11-10 Network Controllability-Based Prioritization of Candidates for SARS-CoV-2 Drug Repositioning Ackerman, Emily E. Shoemaker, Jason E. Viruses Article In a short time, the COVID-19 pandemic has left the world with over 25 million cases and staggering death tolls that are still rising. Treatments for SARS-CoV-2 infection are desperately needed as there are currently no approved drug therapies. With limited knowledge of viral mechanisms, a network controllability method of prioritizing existing drugs for repurposing efforts is optimal for quickly moving through the drug approval pipeline using limited, available, virus-specific data. Based on network topology and controllability, 16 proteins involved in translation, cellular transport, cellular stress, and host immune response are predicted as regulators of the SARS-CoV-2 infected cell. Of the 16, eight are prioritized as possible drug targets where two, PVR and SCARB1, are previously unexplored. Known compounds targeting these genes are suggested for viral inhibition study. Prioritized proteins in agreement with previous analysis and viral inhibition studies verify the ability of network controllability to predict biologically relevant candidates. MDPI 2020-09-26 /pmc/articles/PMC7650805/ /pubmed/32993136 http://dx.doi.org/10.3390/v12101087 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Ackerman, Emily E. Shoemaker, Jason E. Network Controllability-Based Prioritization of Candidates for SARS-CoV-2 Drug Repositioning |
title | Network Controllability-Based Prioritization of Candidates for SARS-CoV-2 Drug Repositioning |
title_full | Network Controllability-Based Prioritization of Candidates for SARS-CoV-2 Drug Repositioning |
title_fullStr | Network Controllability-Based Prioritization of Candidates for SARS-CoV-2 Drug Repositioning |
title_full_unstemmed | Network Controllability-Based Prioritization of Candidates for SARS-CoV-2 Drug Repositioning |
title_short | Network Controllability-Based Prioritization of Candidates for SARS-CoV-2 Drug Repositioning |
title_sort | network controllability-based prioritization of candidates for sars-cov-2 drug repositioning |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7650805/ https://www.ncbi.nlm.nih.gov/pubmed/32993136 http://dx.doi.org/10.3390/v12101087 |
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