SOX2 promotes resistance of melanoma with PD-L1 high expression to T-cell-mediated cytotoxicity that can be reversed by SAHA

BACKGROUND: Immune checkpoint inhibitors (ICIs) induce better tumor regression in melanoma with programmed cell death 1 ligand 1 (PD-L1) high expression, but there has been an upsurge of failed responses. In this study, we aimed to explore the additional mechanisms possibly accounting for ICIs resis...

Descripción completa

Detalles Bibliográficos
Autores principales: Wu, Ruiyan, Wang, Caiqin, Li, Zhiming, Xiao, Jian, Li, Chunyan, Wang, Xuemin, Kong, Pengfei, Cao, Jianghua, Huang, Fuxue, Li, Zhiling, Huang, Yun, Chen, Yuhong, Li, Xuan, Yang, Dong, Zhang, Hailiang, Mai, Jia, Feng, Gongkan, Deng, Rong, Zhu, Xiaofeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2020
Materias:
Clinical/Translational Cancer Immunotherapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7651737/
https://www.ncbi.nlm.nih.gov/pubmed/33158915
http://dx.doi.org/10.1136/jitc-2020-001037

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7651737/
https://www.ncbi.nlm.nih.gov/pubmed/33158915
http://dx.doi.org/10.1136/jitc-2020-001037

Ejemplares similares