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SOX2 promotes resistance of melanoma with PD-L1 high expression to T-cell-mediated cytotoxicity that can be reversed by SAHA

BACKGROUND: Immune checkpoint inhibitors (ICIs) induce better tumor regression in melanoma with programmed cell death 1 ligand 1 (PD-L1) high expression, but there has been an upsurge of failed responses. In this study, we aimed to explore the additional mechanisms possibly accounting for ICIs resis...

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Detalles Bibliográficos
Autores principales:	Wu, Ruiyan, Wang, Caiqin, Li, Zhiming, Xiao, Jian, Li, Chunyan, Wang, Xuemin, Kong, Pengfei, Cao, Jianghua, Huang, Fuxue, Li, Zhiling, Huang, Yun, Chen, Yuhong, Li, Xuan, Yang, Dong, Zhang, Hailiang, Mai, Jia, Feng, Gongkan, Deng, Rong, Zhu, Xiaofeng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2020
Materias:	Clinical/Translational Cancer Immunotherapy
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7651737/ https://www.ncbi.nlm.nih.gov/pubmed/33158915 http://dx.doi.org/10.1136/jitc-2020-001037

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