Analysis of tumor-infiltrating NK and T cells highlights IL-15 stimulation and TIGIT blockade as a combination immunotherapy strategy for soft tissue sarcomas

PURPOSE: Given the unmet need for novel immunotherapy in soft tissue sarcoma (STS), we sought to characterize the phenotype and function of intratumoral natural killer (NK) and T cells to identify novel strategies to augment tumor-infiltrating lymphocyte (TIL) function. EXPERIMENTAL DESIGN: Using pr...

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Detalles Bibliográficos
Autores principales: Judge, Sean J, Darrow, Morgan A, Thorpe, Steve W, Gingrich, Alicia A, O'Donnell, Edmond F, Bellini, Alyssa R, Sturgill, Ian R, Vick, Logan V, Dunai, Cordelia, Stoffel, Kevin M, Lyu, Yue, Chen, Shuai, Cho, May, Rebhun, Robert B, Monjazeb, Arta M, Murphy, William J, Canter, Robert J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2020
Materias:
Clinical/Translational Cancer Immunotherapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7651745/
https://www.ncbi.nlm.nih.gov/pubmed/33158916
http://dx.doi.org/10.1136/jitc-2020-001355

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7651745/
https://www.ncbi.nlm.nih.gov/pubmed/33158916
http://dx.doi.org/10.1136/jitc-2020-001355

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