Cargando…

Analysis of tumor-infiltrating NK and T cells highlights IL-15 stimulation and TIGIT blockade as a combination immunotherapy strategy for soft tissue sarcomas

PURPOSE: Given the unmet need for novel immunotherapy in soft tissue sarcoma (STS), we sought to characterize the phenotype and function of intratumoral natural killer (NK) and T cells to identify novel strategies to augment tumor-infiltrating lymphocyte (TIL) function. EXPERIMENTAL DESIGN: Using pr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Judge, Sean J, Darrow, Morgan A, Thorpe, Steve W, Gingrich, Alicia A, O'Donnell, Edmond F, Bellini, Alyssa R, Sturgill, Ian R, Vick, Logan V, Dunai, Cordelia, Stoffel, Kevin M, Lyu, Yue, Chen, Shuai, Cho, May, Rebhun, Robert B, Monjazeb, Arta M, Murphy, William J, Canter, Robert J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2020
Materias:	Clinical/Translational Cancer Immunotherapy
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7651745/ https://www.ncbi.nlm.nih.gov/pubmed/33158916 http://dx.doi.org/10.1136/jitc-2020-001355

Ejemplares similares

Transcriptome Analysis of Tumor-Infiltrating Lymphocytes Identifies NK Cell Gene Signatures Associated With Lymphocyte Infiltration and Survival in Soft Tissue Sarcomas
por: Judge, Sean J., et al.
Publicado: (2022)

Human soft tissue sarcomas harbor an intratumoral viral microbiome which is linked with natural killer cell infiltrate and prognosis
por: Perry, Lauren M, et al.
Publicado: (2023)

Mouse Preclinical Cancer Immunotherapy Modeling Involving Anti-PD-1 Therapies Reveals the Need to Use Mouse Reagents to Mirror Clinical Paradigms
por: Monjazeb, Arta M., et al.
Publicado: (2021)

Aging augments obesity-induced thymic involution and peripheral T cell exhaustion altering the “obesity paradox”
por: Vick, Logan V., et al.
Publicado: (2023)

Intratumoral NKp46(+) natural killer cells are spatially distanced from T and MHC-I(+) cells with prognostic implications in soft tissue sarcoma
por: Cruz, Sylvia M., et al.
Publicado: (2023)

Regulation of human and mouse bystander T cell activation responses by PD-1
por: Le, Catherine T., et al.
Publicado: (2023)

Mechanisms by Which Obesity Promotes Acute Graft-Versus-Host Disease in Mice
por: Khuat, Lam T., et al.
Publicado: (2021)

PD-1 Blockade Reverses Obesity-Mediated T Cell Priming Impairment
por: Le, Catherine T., et al.
Publicado: (2020)

Blood and tissue biomarker analysis in dogs with osteosarcoma treated with palliative radiation and intra-tumoral autologous natural killer cell transfer
por: Judge, Sean J., et al.
Publicado: (2020)

Inhaled recombinant human IL-15 in dogs with naturally occurring pulmonary metastases from osteosarcoma or melanoma: a phase 1 study of clinical activity and correlates of response
por: Rebhun, Robert B, et al.
Publicado: (2022)

Nectin4 is a novel TIGIT ligand which combines checkpoint inhibition and tumor specificity
por: Reches, Adi, et al.
Publicado: (2020)

TIGIT/CD155 axis mediates resistance to immunotherapy in patients with melanoma with the inflamed tumor microenvironment
por: Kawashima, Shusuke, et al.
Publicado: (2021)

Role of Radiation Therapy in Adult Extraskeletal Ewing's Sarcoma Patients Treated with Chemotherapy and Surgery
por: Saiz, Augustine M., et al.
Publicado: (2019)

T Cell Immune Profiles of Blood and Tumor in Dogs Diagnosed With Malignant Melanoma
por: Sparger, Ellen E., et al.
Publicado: (2021)

TIGIT blockade repolarizes AML-associated TIGIT(+) M2 macrophages to an M1 phenotype and increases CD47-mediated phagocytosis
por: Brauneck, Franziska, et al.
Publicado: (2022)

Head and Neck Cutaneous Soft-Tissue Sarcoma Demonstrate Sex and Racial/Ethnic Disparities in Incidence and Socioeconomic Disparities in Survival
por: Jawad, Muhammad Umar, et al.
Publicado: (2022)

Activation status dictates the function of unlicensed natural killer cells in mice and humans
por: Aguilar, Ethan G., et al.
Publicado: (2021)

TIGIT is a key inhibitory checkpoint receptor in lymphoma
por: Godfrey, James, et al.
Publicado: (2023)

Comparative Immunogenomics of Canine Natural Killer Cells as Immunotherapy Target
por: Gingrich, Alicia A., et al.
Publicado: (2021)

Missing a “Missing Self” Mechanism: Modeling and Detection of Ly49 Expression in Canine NK Cells
por: Gingrich, Alicia A., et al.
Publicado: (2023)

PD-1 and TIGIT coexpression identifies a circulating CD8 T cell subset predictive of response to anti-PD-1 therapy
por: Simon, Sylvain, et al.
Publicado: (2020)

Characterizing the Dysfunctional NK Cell: Assessing the Clinical Relevance of Exhaustion, Anergy, and Senescence
por: Judge, Sean J., et al.
Publicado: (2020)

Combination radioimmunotherapy with adoptive NK transfer targets cancer stem cells in canine models of bone and soft tissue sarcoma
por: Canter, Robert, et al.
Publicado: (2015)

Canine cancer immunotherapy studies: linking mouse and human
por: Park, Jiwon S., et al.
Publicado: (2016)

Natural Killer and T Cell Infiltration in Canine Osteosarcoma: Clinical Implications and Translational Relevance
por: Razmara, Aryana M., et al.
Publicado: (2021)

Bortezomib Augments Natural Killer Cell Targeting of Stem-Like Tumor Cells
por: Luna, Jesus I., et al.
Publicado: (2019)

Enhanced natural killer cell targeting of cancer stem cells using Cetuximab
por: Grossenbacher, Steven K, et al.
Publicado: (2014)

Allelic variation of KIR and HLA tunes the cytolytic payload and determines functional hierarchy of NK cell repertoires
por: Philippon, Camille, et al.
Publicado: (2023)

Principles and current clinical landscape of NK cell engaging bispecific antibody against cancer
por: Huan, Tian, et al.
Publicado: (2023)

TIGIT blockade enhances functionality of peritoneal NK cells with altered expression of DNAM-1/TIGIT/CD96 checkpoint molecules in ovarian cancer
por: Maas, Ralph Ja, et al.
Publicado: (2020)

Paradoxical effects of obesity on T cell function during tumor progression and PD-1 checkpoint blockade
por: Wang, Ziming, et al.
Publicado: (2018)

An engineered oncolytic vaccinia virus encoding a single-chain variable fragment against TIGIT induces effective antitumor immunity and synergizes with PD-1 or LAG-3 blockade
por: Zuo, Shuguang, et al.
Publicado: (2021)

Intratumoral TIGIT(+) CD8(+) T-cell infiltration determines poor prognosis and immune evasion in patients with muscle-invasive bladder cancer
por: Liu, Zhaopei, et al.
Publicado: (2020)

Defining the AHR-regulated transcriptome in NK cells reveals gene expression programs relevant to development and function
por: Trikha, Prashant, et al.
Publicado: (2021)

Interleukin-15 augments NK cell–mediated ADCC of alemtuzumab in patients with CD52(+) T-cell malignancies
por: Miljkovic, Milos D., et al.
Publicado: (2022)

Overexpression of TIGIT in NK and T Cells Contributes to Tumor Immune Escape in Myelodysplastic Syndromes
por: Meng, Fanqiao, et al.
Publicado: (2020)

Targeting hypersialylation in multiple myeloma represents a novel approach to enhance NK cell–mediated tumor responses
por: Daly, John, et al.
Publicado: (2022)

The co-inhibitory receptor TIGIT regulates NK cell function and is upregulated in human intrahepatic CD56(bright) NK cells
por: Ziegler, Annerose E., et al.
Publicado: (2023)

NK cells CD56(bright) and CD56(dim) subset cytokine loss and exhaustion is associated with impaired survival in myeloma
por: Seymour, Frances, et al.
Publicado: (2022)

IMMU-30. UPREGULATED T CELL AND INTERFERON-Γ-RELATED GENE EXPRESSION IS ASSOCIATED WITH INCREASED SURVIVAL IN RECURRENT PEDIATRIC HIGH-GRADE GLIOMA
por: Davidson, Tom, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_q59qt4et4e7ptb9tlqv7ci7a3m