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Ubiquitin–proteasome system (UPS) as a target for anticancer treatment
The ubiquitin–proteasome system (UPS) plays an important role in the cellular processes for protein quality control and homeostasis. Dysregulation of the UPS has been implicated in numerous diseases, including cancer. Indeed, components of UPS are frequently mutated or abnormally expressed in variou...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Pharmaceutical Society of Korea
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7651821/ https://www.ncbi.nlm.nih.gov/pubmed/33165832 http://dx.doi.org/10.1007/s12272-020-01281-8 |
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author | Park, Jinyoung Cho, Jinhong Song, Eun Joo |
author_facet | Park, Jinyoung Cho, Jinhong Song, Eun Joo |
author_sort | Park, Jinyoung |
collection | PubMed |
description | The ubiquitin–proteasome system (UPS) plays an important role in the cellular processes for protein quality control and homeostasis. Dysregulation of the UPS has been implicated in numerous diseases, including cancer. Indeed, components of UPS are frequently mutated or abnormally expressed in various cancers. Since Bortezomib, a proteasome inhibitor, received FDA approval for the treatment of multiple myeloma and mantle cell lymphoma, increasing numbers of researchers have been seeking drugs targeting the UPS as a cancer therapeutic strategy. Here, we introduce the essential component of UPS, including ubiquitinating enzymes, deubiquitinating enzymes and 26S proteasome, and we summarize their targets and mechanisms that are crucial for tumorigenesis. In addition, we briefly discuss some UPS inhibitors, which are currently in clinical trials as cancer therapeutics. |
format | Online Article Text |
id | pubmed-7651821 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Pharmaceutical Society of Korea |
record_format | MEDLINE/PubMed |
spelling | pubmed-76518212020-11-10 Ubiquitin–proteasome system (UPS) as a target for anticancer treatment Park, Jinyoung Cho, Jinhong Song, Eun Joo Arch Pharm Res Review The ubiquitin–proteasome system (UPS) plays an important role in the cellular processes for protein quality control and homeostasis. Dysregulation of the UPS has been implicated in numerous diseases, including cancer. Indeed, components of UPS are frequently mutated or abnormally expressed in various cancers. Since Bortezomib, a proteasome inhibitor, received FDA approval for the treatment of multiple myeloma and mantle cell lymphoma, increasing numbers of researchers have been seeking drugs targeting the UPS as a cancer therapeutic strategy. Here, we introduce the essential component of UPS, including ubiquitinating enzymes, deubiquitinating enzymes and 26S proteasome, and we summarize their targets and mechanisms that are crucial for tumorigenesis. In addition, we briefly discuss some UPS inhibitors, which are currently in clinical trials as cancer therapeutics. Pharmaceutical Society of Korea 2020-11-09 2020 /pmc/articles/PMC7651821/ /pubmed/33165832 http://dx.doi.org/10.1007/s12272-020-01281-8 Text en © The Pharmaceutical Society of Korea 2020 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Review Park, Jinyoung Cho, Jinhong Song, Eun Joo Ubiquitin–proteasome system (UPS) as a target for anticancer treatment |
title | Ubiquitin–proteasome system (UPS) as a target for anticancer treatment |
title_full | Ubiquitin–proteasome system (UPS) as a target for anticancer treatment |
title_fullStr | Ubiquitin–proteasome system (UPS) as a target for anticancer treatment |
title_full_unstemmed | Ubiquitin–proteasome system (UPS) as a target for anticancer treatment |
title_short | Ubiquitin–proteasome system (UPS) as a target for anticancer treatment |
title_sort | ubiquitin–proteasome system (ups) as a target for anticancer treatment |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7651821/ https://www.ncbi.nlm.nih.gov/pubmed/33165832 http://dx.doi.org/10.1007/s12272-020-01281-8 |
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