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SARS-CoV-2 antibody prevalence, titres and neutralising activity in an antenatal cohort, United Kingdom, 14 April to 15 June 2020
SARS-CoV-2 IgG screening of 1,000 antenatal serum samples in the Oxford area, United Kingdom, between 14 April and 15 June 2020, yielded a 5.3% seroprevalence, mirroring contemporaneous regional data. Among the 53 positive samples, 39 showed in vitro neutralisation activity, correlating with IgG tit...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
European Centre for Disease Prevention and Control (ECDC)
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7651878/ https://www.ncbi.nlm.nih.gov/pubmed/33094717 http://dx.doi.org/10.2807/1560-7917.ES.2020.25.41.2001721 |
| _version_ | 1783607614032052224 |
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| author | Lumley, Sheila F Eyre, David W McNaughton, Anna L Howarth, Alison Hoosdally, Sarah Hatch, Stephanie B Kavanagh, James Chau, Kevin K Downs, Louise O Cox, Stuart Dunn, Laura Justice, Anita Wareing, Susan Dingle, Kate Rudkin, Justine Auckland, Kathryn Fyfe, Alexander Bolton, Jai Paton, Robert Mentzer, Alexander J Jeffery, Katie Andersson, Monique I James, Tim Peto, Tim E A Marsden, Brian D Screaton, Gavin Cornall, Richard J Klenerman, Paul Ebner, Daniel Stuart, David I Crook, Derrick W Stoesser, Nicole Kennedy, Stephen H Thompson, Craig Gupta, Sunetra Matthews, Philippa C |
| author_facet | Lumley, Sheila F Eyre, David W McNaughton, Anna L Howarth, Alison Hoosdally, Sarah Hatch, Stephanie B Kavanagh, James Chau, Kevin K Downs, Louise O Cox, Stuart Dunn, Laura Justice, Anita Wareing, Susan Dingle, Kate Rudkin, Justine Auckland, Kathryn Fyfe, Alexander Bolton, Jai Paton, Robert Mentzer, Alexander J Jeffery, Katie Andersson, Monique I James, Tim Peto, Tim E A Marsden, Brian D Screaton, Gavin Cornall, Richard J Klenerman, Paul Ebner, Daniel Stuart, David I Crook, Derrick W Stoesser, Nicole Kennedy, Stephen H Thompson, Craig Gupta, Sunetra Matthews, Philippa C |
| author_sort | Lumley, Sheila F |
| collection | PubMed |
| description | SARS-CoV-2 IgG screening of 1,000 antenatal serum samples in the Oxford area, United Kingdom, between 14 April and 15 June 2020, yielded a 5.3% seroprevalence, mirroring contemporaneous regional data. Among the 53 positive samples, 39 showed in vitro neutralisation activity, correlating with IgG titre (Pearson’s correlation p<0.0001). While SARS-CoV-2 seroprevalence in pregnancy cohorts could potentially inform population surveillance, clinical correlates of infection and immunity in pregnancy, and antenatal epidemiology evolution over time need further study. |
| format | Online Article Text |
| id | pubmed-7651878 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2020 |
| publisher | European Centre for Disease Prevention and Control (ECDC) |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-76518782020-11-17 SARS-CoV-2 antibody prevalence, titres and neutralising activity in an antenatal cohort, United Kingdom, 14 April to 15 June 2020 Lumley, Sheila F Eyre, David W McNaughton, Anna L Howarth, Alison Hoosdally, Sarah Hatch, Stephanie B Kavanagh, James Chau, Kevin K Downs, Louise O Cox, Stuart Dunn, Laura Justice, Anita Wareing, Susan Dingle, Kate Rudkin, Justine Auckland, Kathryn Fyfe, Alexander Bolton, Jai Paton, Robert Mentzer, Alexander J Jeffery, Katie Andersson, Monique I James, Tim Peto, Tim E A Marsden, Brian D Screaton, Gavin Cornall, Richard J Klenerman, Paul Ebner, Daniel Stuart, David I Crook, Derrick W Stoesser, Nicole Kennedy, Stephen H Thompson, Craig Gupta, Sunetra Matthews, Philippa C Euro Surveill Rapid Communication SARS-CoV-2 IgG screening of 1,000 antenatal serum samples in the Oxford area, United Kingdom, between 14 April and 15 June 2020, yielded a 5.3% seroprevalence, mirroring contemporaneous regional data. Among the 53 positive samples, 39 showed in vitro neutralisation activity, correlating with IgG titre (Pearson’s correlation p<0.0001). While SARS-CoV-2 seroprevalence in pregnancy cohorts could potentially inform population surveillance, clinical correlates of infection and immunity in pregnancy, and antenatal epidemiology evolution over time need further study. European Centre for Disease Prevention and Control (ECDC) 2020-10-22 /pmc/articles/PMC7651878/ /pubmed/33094717 http://dx.doi.org/10.2807/1560-7917.ES.2020.25.41.2001721 Text en This article is copyright of the authors or their affiliated institutions, 2020. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made. |
| spellingShingle | Rapid Communication Lumley, Sheila F Eyre, David W McNaughton, Anna L Howarth, Alison Hoosdally, Sarah Hatch, Stephanie B Kavanagh, James Chau, Kevin K Downs, Louise O Cox, Stuart Dunn, Laura Justice, Anita Wareing, Susan Dingle, Kate Rudkin, Justine Auckland, Kathryn Fyfe, Alexander Bolton, Jai Paton, Robert Mentzer, Alexander J Jeffery, Katie Andersson, Monique I James, Tim Peto, Tim E A Marsden, Brian D Screaton, Gavin Cornall, Richard J Klenerman, Paul Ebner, Daniel Stuart, David I Crook, Derrick W Stoesser, Nicole Kennedy, Stephen H Thompson, Craig Gupta, Sunetra Matthews, Philippa C SARS-CoV-2 antibody prevalence, titres and neutralising activity in an antenatal cohort, United Kingdom, 14 April to 15 June 2020 |
| title | SARS-CoV-2 antibody prevalence, titres and neutralising activity in an antenatal cohort, United Kingdom, 14 April to 15 June 2020 |
| title_full | SARS-CoV-2 antibody prevalence, titres and neutralising activity in an antenatal cohort, United Kingdom, 14 April to 15 June 2020 |
| title_fullStr | SARS-CoV-2 antibody prevalence, titres and neutralising activity in an antenatal cohort, United Kingdom, 14 April to 15 June 2020 |
| title_full_unstemmed | SARS-CoV-2 antibody prevalence, titres and neutralising activity in an antenatal cohort, United Kingdom, 14 April to 15 June 2020 |
| title_short | SARS-CoV-2 antibody prevalence, titres and neutralising activity in an antenatal cohort, United Kingdom, 14 April to 15 June 2020 |
| title_sort | sars-cov-2 antibody prevalence, titres and neutralising activity in an antenatal cohort, united kingdom, 14 april to 15 june 2020 |
| topic | Rapid Communication |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7651878/ https://www.ncbi.nlm.nih.gov/pubmed/33094717 http://dx.doi.org/10.2807/1560-7917.ES.2020.25.41.2001721 |
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