Cargando…

Recent developments in anticancer kinase inhibitors based on the pyrazolo[3,4-d]pyrimidine scaffold

Pyrazolo[3,4-d]pyrimidines have become of significant interest for the medicinal chemistry community as a privileged scaffold for the development of kinase inhibitors to treat a range of diseases, including cancer. This fused nitrogen-containing heterocycle is an isostere of the adenine ring of ATP,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Baillache, Daniel J., Unciti-Broceta, Asier
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Royal Society of Chemistry 2020
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7652001/ https://www.ncbi.nlm.nih.gov/pubmed/33479617 http://dx.doi.org/10.1039/d0md00227e

Ejemplares similares

Discovery of a potent protein kinase D inhibitor: insights in the binding mode of pyrazolo[3,4-d]pyrimidine analogues
por: Verschueren, Klaas, et al.
Publicado: (2017)

Synthesis and Antibacterial Evaluation of New Pyrazolo[3,4-d]pyrimidines Kinase Inhibitors
por: Greco, Chiara, et al.
Publicado: (2020)

Discovery of pyrazolo[3,4-d]pyrimidine and pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine derivatives as novel CDK2 inhibitors: synthesis, biological and molecular modeling investigations
por: Nassar, Ibrahim F., et al.
Publicado: (2022)

Synthesis and Anticancer Activity of Some New Pyrazolo[3,4-d]pyrimidin-4-one Derivatives
por: Abdellatif, Khaled R. A., et al.
Publicado: (2014)

Autophagy Inhibition Enhances Anti-Glioblastoma Effects of Pyrazolo[3,4-d]pyrimidine Tyrosine Kinase Inhibitors
por: Jovanović Stojanov, Sofija, et al.
Publicado: (2022)

4-Hydrazino-1-methylpyrazolo[3,4-d]pyrimidine
por: Dolzhenko, Anton V., et al.
Publicado: (2009)

Three-component microwave-assisted synthesis of 3,5-disubstituted pyrazolo[3,4-d]pyrimidin-4-ones
por: Ng, Jia Hui, et al.
Publicado: (2022)

Computational Approaches for the Design of Novel Anticancer Compounds Based on Pyrazolo[3,4-d]pyrimidine Derivatives as TRAP1 Inhibitor
por: Ali, Amena, et al.
Publicado: (2021)

Identification of 6-amino-1H-pyrazolo[3,4-d]pyrimidines with in vivo efficacy against visceral leishmaniasis
por: Thomas, Michael G., et al.
Publicado: (2020)

Pyrazolo[3,4-d]pyrimidine Tyrosine Kinase Inhibitors Induce Oxidative Stress in Patient-Derived Glioblastoma Cells
por: Kostić, Ana, et al.
Publicado: (2021)

4-Benzylsulfanyl-1H-pyrazolo[3,4-d]pyrimidine
por: El Fal, Mohammed, et al.
Publicado: (2013)

The Role of Pyrazolo[3,4-d]pyrimidine-Based Kinase Inhibitors in The Attenuation of CCl(4)-Induced Liver Fibrosis in Rats
por: Ghobrial, Diana K., et al.
Publicado: (2023)

Pyrazolopyrimide library screening in glioma cells discovers highly potent antiproliferative leads that target the PI3K/mTOR pathway
por: Valero, Teresa, et al.
Publicado: (2020)

Zika Virus Inhibitors Based on a 1,3-Disubstituted 1H-Pyrazolo[3,4-d]pyrimidine-amine Scaffold
por: Jung, Eunkyung, et al.
Publicado: (2022)

New Therapeutic Strategy for Overcoming Multidrug Resistance in Cancer Cells with Pyrazolo[3,4-d]pyrimidine Tyrosine Kinase Inhibitors
por: Podolski-Renić, Ana, et al.
Publicado: (2021)

Design, synthesis, and biological evaluation with molecular dynamics study of novel pyrazolo[3,4-d]pyrimidine derivatives as anti-cancer agents
por: Shaban, Rania M., et al.
Publicado: (2023)

Synthesis, biological evaluation, and in silico studies of new CDK2 inhibitors based on pyrazolo[3,4-d]pyrimidine and pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine scaffold with apoptotic activity
por: Mandour, Asmaa A., et al.
Publicado: (2022)

Design, Synthesis, and Anticancer Screening for Repurposed Pyrazolo[3,4-d]pyrimidine Derivatives on Four Mammalian Cancer Cell Lines
por: Othman, Eman M., et al.
Publicado: (2021)

Design, Synthesis, and Antitumor Evaluation of Novel Pyrazolo[3,4-d]pyrimidine Derivatives
por: Kandeel, Manal M., et al.
Publicado: (2012)

Synthesis, characterization and in vitro antimicrobial activity of novel fused pyrazolo[3,4-c]pyridazine, pyrazolo[3,4-d]pyrimidine, thieno[3,2-c]pyrazole and pyrazolo[3′,4′:4,5]thieno[2,3-d]pyrimidine derivatives
por: Abdel Reheim, Mohamed A. M., et al.
Publicado: (2017)

Identification and Biological Characterization of the Pyrazolo[3,4-d]pyrimidine Derivative SI388 Active as Src Inhibitor
por: Contadini, Claudia, et al.
Publicado: (2023)

Crystal structure of 4-allylsulfanyl-1H-pyrazolo[3,4-d]pyrimidine
por: El Fal, Mohammed, et al.
Publicado: (2014)

Correction to: Synthesis, characterization and in vitro antimicrobial activity of novel fused pyrazolo[3,4-c]pyridazine, pyrazolo[3,4-d]pyrimidine, thieno[3,2-c] pyrazole and pyrazolo[3′,4′:4,5]thieno[2,3-d]pyrimidine derivatives
por: Abdel Reheim, Mohamed A. M., et al.
Publicado: (2017)

Improvement of pyrazolo[3,4-d]pyrimidines pharmacokinetic properties: nanosystem approaches for drug delivery
por: Vignaroli, Giulia, et al.
Publicado: (2016)

Crystal structure of 1-ethylpyrazolo[3,4-d]pyrimidine-4(5H)-thione
por: El Fal, Mohammed, et al.
Publicado: (2014)

Discovery of new 1H-pyrazolo[3,4-d]pyrimidine derivatives as anticancer agents targeting EGFR(WT) and EGFR(T790M)
por: Gaber, Ahmed A., et al.
Publicado: (2022)

Synthesis and vectorial functionalisation of pyrazolo[3,4-c]pyridines
por: Bedwell, Elizabeth V., et al.
Publicado: (2023)

Synthesis and Antimicrobial Activity of Some New Pyrazole, Fused Pyrazolo[3,4-d]-pyrimidine and Pyrazolo[4,3-e][1,2,4]-triazolo[1,5-c]pyrimidine Derivatives
por: Abunada, Nada M., et al.
Publicado: (2008)

One-Flask Synthesis of Pyrazolo[3,4-d]pyrimidines from 5-Aminopyrazoles and Mechanistic Study
por: Yen, Wan-Ping, et al.
Publicado: (2017)

Heterocyclic o-Aminonitriles: Preparation of Pyrazolo[3,4-d]-pyrimidines with Modification of the Substituents at the 1-Position
por: Al-Afaleq, Eljazi I., et al.
Publicado: (2001)

Crystal structure of 1-methyl-4-methylsulfanyl-1H-pyrazolo[3,4-d]pyrimidine
por: El Fal, Mohammed, et al.
Publicado: (2014)

Biological Evaluation and In Vitro Characterization of ADME Profile of In-House Pyrazolo[3,4-d]pyrimidines as Dual Tyrosine Kinase Inhibitors Active against Glioblastoma Multiforme
por: Poggialini, Federica, et al.
Publicado: (2023)

Regioselectivity of 1,3-dipolar cycloadditions and antimicrobial activity of isoxazoline, pyrrolo[3,4-d]isoxazole-4,6-diones, pyrazolo[3,4-d]pyridazines and pyrazolo[1,5-a]pyrimidines
por: Zaki, Yasser Hassan, et al.
Publicado: (2016)

Novel Glu-based pyrazolo[3,4-d]pyrimidine analogues: design, synthesis and biological evaluation as DHFR and TS dual inhibitors
por: Mahnashi, Mater, et al.
Publicado: (2023)

A convenient four-component one-pot strategy toward the synthesis of pyrazolo[3,4-d]pyrimidines
por: Liu, Mingxing, et al.
Publicado: (2015)

Synthesis, Anti-Inflammatory, and Ulcerogenicity Studies of Novel Substituted and Fused Pyrazolo[3,4-d]pyrimidin-4-ones
por: El-Tombary, Alaa A.
Publicado: (2013)

5-(Pyridin-4-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one
por: Alsubari, Abdulsalam, et al.
Publicado: (2011)

Design, synthesis and antitumor evaluation of novel pyrazolo[3,4-d]pyrimidines incorporating different amino acid conjugates as potential DHFR inhibitors
por: Salem, Ibrahim M., et al.
Publicado: (2022)

Src Inhibitors Pyrazolo[3,4-d]pyrimidines, Si306 and Pro-Si306, Inhibit Focal Adhesion Kinase and Suppress Human Glioblastoma Invasion In Vitro and In Vivo
por: Nešović, Marija, et al.
Publicado: (2020)

A Pyrazolo[3,4-d]pyrimidine Compound Reduces Cell Viability and Induces Apoptosis in Different Hematological Malignancies
por: Laurenzana, Ilaria, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_meqef51pm0cjljgcptssccev7s