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Variation by lineage in serum antibody responses to influenza B virus infections

Two lineages of influenza B virus currently co-circulate and have distinct antigenicity, termed Victoria and Yamagata after the B/Victoria/2/87 and B/Yamagata/16/88 strains, respectively. We analyzed antibody titer dynamics following PCR-confirmed influenza B virus infection in a longitudinal commun...

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Autores principales: Lau, Yiu Chung, Perera, Ranawaka A. P. M., Fang, Vicky J., Luk, Long Hei, Chu, Daniel K. W., Wu, Peng, Barr, Ian G., Peiris, J. S. Malik, Cowling, Benjamin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7652285/
https://www.ncbi.nlm.nih.gov/pubmed/33166348
http://dx.doi.org/10.1371/journal.pone.0241693
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author Lau, Yiu Chung
Perera, Ranawaka A. P. M.
Fang, Vicky J.
Luk, Long Hei
Chu, Daniel K. W.
Wu, Peng
Barr, Ian G.
Peiris, J. S. Malik
Cowling, Benjamin J.
author_facet Lau, Yiu Chung
Perera, Ranawaka A. P. M.
Fang, Vicky J.
Luk, Long Hei
Chu, Daniel K. W.
Wu, Peng
Barr, Ian G.
Peiris, J. S. Malik
Cowling, Benjamin J.
author_sort Lau, Yiu Chung
collection PubMed
description Two lineages of influenza B virus currently co-circulate and have distinct antigenicity, termed Victoria and Yamagata after the B/Victoria/2/87 and B/Yamagata/16/88 strains, respectively. We analyzed antibody titer dynamics following PCR-confirmed influenza B virus infection in a longitudinal community-based cohort study conducted in Hong Kong from 2009–2014 to assess patterns in changes in antibody titers to B/Victoria and B/Yamagata viruses following infections with each lineage. Among 62 PCR-confirmed cases, almost half had undetectable hemagglutination inhibition (HAI) antibody titers to the lineage of infection both pre-infection and post-infection. Among those infected with influenza B/Victoria who showed an HAI titer response after infection, we found strong rises to the lineage of infection, positive but smaller cross-lineage HAI titer boosts, a small dependence of HAI titer boosts on pre-infection titers, and a shorter half-life of HAI titers in adults. Our study is limited by the low HAI sensitivity for non-ether-treated IBV antigen and the incapacity of performing other assays with higher sensitivity, as well as the mismatch between the B/Yamagata lineage circulating strain and the assay strain in one of the study seasons.
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spelling pubmed-76522852020-11-18 Variation by lineage in serum antibody responses to influenza B virus infections Lau, Yiu Chung Perera, Ranawaka A. P. M. Fang, Vicky J. Luk, Long Hei Chu, Daniel K. W. Wu, Peng Barr, Ian G. Peiris, J. S. Malik Cowling, Benjamin J. PLoS One Research Article Two lineages of influenza B virus currently co-circulate and have distinct antigenicity, termed Victoria and Yamagata after the B/Victoria/2/87 and B/Yamagata/16/88 strains, respectively. We analyzed antibody titer dynamics following PCR-confirmed influenza B virus infection in a longitudinal community-based cohort study conducted in Hong Kong from 2009–2014 to assess patterns in changes in antibody titers to B/Victoria and B/Yamagata viruses following infections with each lineage. Among 62 PCR-confirmed cases, almost half had undetectable hemagglutination inhibition (HAI) antibody titers to the lineage of infection both pre-infection and post-infection. Among those infected with influenza B/Victoria who showed an HAI titer response after infection, we found strong rises to the lineage of infection, positive but smaller cross-lineage HAI titer boosts, a small dependence of HAI titer boosts on pre-infection titers, and a shorter half-life of HAI titers in adults. Our study is limited by the low HAI sensitivity for non-ether-treated IBV antigen and the incapacity of performing other assays with higher sensitivity, as well as the mismatch between the B/Yamagata lineage circulating strain and the assay strain in one of the study seasons. Public Library of Science 2020-11-09 /pmc/articles/PMC7652285/ /pubmed/33166348 http://dx.doi.org/10.1371/journal.pone.0241693 Text en © 2020 Lau et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Lau, Yiu Chung
Perera, Ranawaka A. P. M.
Fang, Vicky J.
Luk, Long Hei
Chu, Daniel K. W.
Wu, Peng
Barr, Ian G.
Peiris, J. S. Malik
Cowling, Benjamin J.
Variation by lineage in serum antibody responses to influenza B virus infections
title Variation by lineage in serum antibody responses to influenza B virus infections
title_full Variation by lineage in serum antibody responses to influenza B virus infections
title_fullStr Variation by lineage in serum antibody responses to influenza B virus infections
title_full_unstemmed Variation by lineage in serum antibody responses to influenza B virus infections
title_short Variation by lineage in serum antibody responses to influenza B virus infections
title_sort variation by lineage in serum antibody responses to influenza b virus infections
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7652285/
https://www.ncbi.nlm.nih.gov/pubmed/33166348
http://dx.doi.org/10.1371/journal.pone.0241693
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