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Variation by lineage in serum antibody responses to influenza B virus infections
Two lineages of influenza B virus currently co-circulate and have distinct antigenicity, termed Victoria and Yamagata after the B/Victoria/2/87 and B/Yamagata/16/88 strains, respectively. We analyzed antibody titer dynamics following PCR-confirmed influenza B virus infection in a longitudinal commun...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7652285/ https://www.ncbi.nlm.nih.gov/pubmed/33166348 http://dx.doi.org/10.1371/journal.pone.0241693 |
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author | Lau, Yiu Chung Perera, Ranawaka A. P. M. Fang, Vicky J. Luk, Long Hei Chu, Daniel K. W. Wu, Peng Barr, Ian G. Peiris, J. S. Malik Cowling, Benjamin J. |
author_facet | Lau, Yiu Chung Perera, Ranawaka A. P. M. Fang, Vicky J. Luk, Long Hei Chu, Daniel K. W. Wu, Peng Barr, Ian G. Peiris, J. S. Malik Cowling, Benjamin J. |
author_sort | Lau, Yiu Chung |
collection | PubMed |
description | Two lineages of influenza B virus currently co-circulate and have distinct antigenicity, termed Victoria and Yamagata after the B/Victoria/2/87 and B/Yamagata/16/88 strains, respectively. We analyzed antibody titer dynamics following PCR-confirmed influenza B virus infection in a longitudinal community-based cohort study conducted in Hong Kong from 2009–2014 to assess patterns in changes in antibody titers to B/Victoria and B/Yamagata viruses following infections with each lineage. Among 62 PCR-confirmed cases, almost half had undetectable hemagglutination inhibition (HAI) antibody titers to the lineage of infection both pre-infection and post-infection. Among those infected with influenza B/Victoria who showed an HAI titer response after infection, we found strong rises to the lineage of infection, positive but smaller cross-lineage HAI titer boosts, a small dependence of HAI titer boosts on pre-infection titers, and a shorter half-life of HAI titers in adults. Our study is limited by the low HAI sensitivity for non-ether-treated IBV antigen and the incapacity of performing other assays with higher sensitivity, as well as the mismatch between the B/Yamagata lineage circulating strain and the assay strain in one of the study seasons. |
format | Online Article Text |
id | pubmed-7652285 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-76522852020-11-18 Variation by lineage in serum antibody responses to influenza B virus infections Lau, Yiu Chung Perera, Ranawaka A. P. M. Fang, Vicky J. Luk, Long Hei Chu, Daniel K. W. Wu, Peng Barr, Ian G. Peiris, J. S. Malik Cowling, Benjamin J. PLoS One Research Article Two lineages of influenza B virus currently co-circulate and have distinct antigenicity, termed Victoria and Yamagata after the B/Victoria/2/87 and B/Yamagata/16/88 strains, respectively. We analyzed antibody titer dynamics following PCR-confirmed influenza B virus infection in a longitudinal community-based cohort study conducted in Hong Kong from 2009–2014 to assess patterns in changes in antibody titers to B/Victoria and B/Yamagata viruses following infections with each lineage. Among 62 PCR-confirmed cases, almost half had undetectable hemagglutination inhibition (HAI) antibody titers to the lineage of infection both pre-infection and post-infection. Among those infected with influenza B/Victoria who showed an HAI titer response after infection, we found strong rises to the lineage of infection, positive but smaller cross-lineage HAI titer boosts, a small dependence of HAI titer boosts on pre-infection titers, and a shorter half-life of HAI titers in adults. Our study is limited by the low HAI sensitivity for non-ether-treated IBV antigen and the incapacity of performing other assays with higher sensitivity, as well as the mismatch between the B/Yamagata lineage circulating strain and the assay strain in one of the study seasons. Public Library of Science 2020-11-09 /pmc/articles/PMC7652285/ /pubmed/33166348 http://dx.doi.org/10.1371/journal.pone.0241693 Text en © 2020 Lau et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Lau, Yiu Chung Perera, Ranawaka A. P. M. Fang, Vicky J. Luk, Long Hei Chu, Daniel K. W. Wu, Peng Barr, Ian G. Peiris, J. S. Malik Cowling, Benjamin J. Variation by lineage in serum antibody responses to influenza B virus infections |
title | Variation by lineage in serum antibody responses to influenza B virus infections |
title_full | Variation by lineage in serum antibody responses to influenza B virus infections |
title_fullStr | Variation by lineage in serum antibody responses to influenza B virus infections |
title_full_unstemmed | Variation by lineage in serum antibody responses to influenza B virus infections |
title_short | Variation by lineage in serum antibody responses to influenza B virus infections |
title_sort | variation by lineage in serum antibody responses to influenza b virus infections |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7652285/ https://www.ncbi.nlm.nih.gov/pubmed/33166348 http://dx.doi.org/10.1371/journal.pone.0241693 |
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