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A cohort study of 676 patients indicates D-dimer is a critical risk factor for the mortality of COVID-19
Coronavirus Disease 2019 (COVID-19) has recently become a public emergency and a worldwide pandemic. However, the information on the risk factors associated with the mortality of COVID-19 and of their prognostic potential is limited. In this retrospective study, the clinical characteristics, treatme...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7652321/ https://www.ncbi.nlm.nih.gov/pubmed/33166991 http://dx.doi.org/10.1371/journal.pone.0242045 |
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author | Huang, Yongsheng Lyu, Xiaoyu Li, Dan Wang, Lin Wang, Yujun Zou, Wenbin Wei, Yingxin Wu, Xiaowei |
author_facet | Huang, Yongsheng Lyu, Xiaoyu Li, Dan Wang, Lin Wang, Yujun Zou, Wenbin Wei, Yingxin Wu, Xiaowei |
author_sort | Huang, Yongsheng |
collection | PubMed |
description | Coronavirus Disease 2019 (COVID-19) has recently become a public emergency and a worldwide pandemic. However, the information on the risk factors associated with the mortality of COVID-19 and of their prognostic potential is limited. In this retrospective study, the clinical characteristics, treatment and outcome data were collected and analyzed from 676 COVID-19 patients stratified into 140 non-survivors and 536 survivors. We found that the levels of Dimerized plasmin fragment D (D-dimer), C-reactive protein (CRP), lactate dehydrogenase (LDH), procalcitonin (PCT) were significantly higher in non-survivals on admission (non-survivors vs. survivors: D-Dimer ≥ 0.5 mg/L, 83.2% vs. 44.9%, P<0.01; CRP ≥10 mg/L, 50.4% vs. 6.0%, P<0.01; LDH ≥ 250 U/L, 73.8% vs. 20.1%, P<0.01; PCT ≥ 0.5 ng/ml, 27.7% vs. 1.8%, P<0.01). Moreover, dynamic tracking showed D-dimer kept increasing in non-survivors, while CRP, LDH and PCT remained relatively stable after admission. D-dimer has the highest C-index to predict in-hospital mortality, and patients with D-dimer levels ≥0.5 mg/L had a higher incidence of mortality (Hazard Ratio: 4.39, P<0.01). Our study suggested D-dimer could be a potent marker to predict the mortality of COVID-19, which may be helpful for the management of patients. |
format | Online Article Text |
id | pubmed-7652321 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-76523212020-11-18 A cohort study of 676 patients indicates D-dimer is a critical risk factor for the mortality of COVID-19 Huang, Yongsheng Lyu, Xiaoyu Li, Dan Wang, Lin Wang, Yujun Zou, Wenbin Wei, Yingxin Wu, Xiaowei PLoS One Research Article Coronavirus Disease 2019 (COVID-19) has recently become a public emergency and a worldwide pandemic. However, the information on the risk factors associated with the mortality of COVID-19 and of their prognostic potential is limited. In this retrospective study, the clinical characteristics, treatment and outcome data were collected and analyzed from 676 COVID-19 patients stratified into 140 non-survivors and 536 survivors. We found that the levels of Dimerized plasmin fragment D (D-dimer), C-reactive protein (CRP), lactate dehydrogenase (LDH), procalcitonin (PCT) were significantly higher in non-survivals on admission (non-survivors vs. survivors: D-Dimer ≥ 0.5 mg/L, 83.2% vs. 44.9%, P<0.01; CRP ≥10 mg/L, 50.4% vs. 6.0%, P<0.01; LDH ≥ 250 U/L, 73.8% vs. 20.1%, P<0.01; PCT ≥ 0.5 ng/ml, 27.7% vs. 1.8%, P<0.01). Moreover, dynamic tracking showed D-dimer kept increasing in non-survivors, while CRP, LDH and PCT remained relatively stable after admission. D-dimer has the highest C-index to predict in-hospital mortality, and patients with D-dimer levels ≥0.5 mg/L had a higher incidence of mortality (Hazard Ratio: 4.39, P<0.01). Our study suggested D-dimer could be a potent marker to predict the mortality of COVID-19, which may be helpful for the management of patients. Public Library of Science 2020-11-09 /pmc/articles/PMC7652321/ /pubmed/33166991 http://dx.doi.org/10.1371/journal.pone.0242045 Text en © 2020 Huang et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Huang, Yongsheng Lyu, Xiaoyu Li, Dan Wang, Lin Wang, Yujun Zou, Wenbin Wei, Yingxin Wu, Xiaowei A cohort study of 676 patients indicates D-dimer is a critical risk factor for the mortality of COVID-19 |
title | A cohort study of 676 patients indicates D-dimer is a critical risk factor for the mortality of COVID-19 |
title_full | A cohort study of 676 patients indicates D-dimer is a critical risk factor for the mortality of COVID-19 |
title_fullStr | A cohort study of 676 patients indicates D-dimer is a critical risk factor for the mortality of COVID-19 |
title_full_unstemmed | A cohort study of 676 patients indicates D-dimer is a critical risk factor for the mortality of COVID-19 |
title_short | A cohort study of 676 patients indicates D-dimer is a critical risk factor for the mortality of COVID-19 |
title_sort | cohort study of 676 patients indicates d-dimer is a critical risk factor for the mortality of covid-19 |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7652321/ https://www.ncbi.nlm.nih.gov/pubmed/33166991 http://dx.doi.org/10.1371/journal.pone.0242045 |
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