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A cohort study of 676 patients indicates D-dimer is a critical risk factor for the mortality of COVID-19

Coronavirus Disease 2019 (COVID-19) has recently become a public emergency and a worldwide pandemic. However, the information on the risk factors associated with the mortality of COVID-19 and of their prognostic potential is limited. In this retrospective study, the clinical characteristics, treatme...

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Autores principales: Huang, Yongsheng, Lyu, Xiaoyu, Li, Dan, Wang, Lin, Wang, Yujun, Zou, Wenbin, Wei, Yingxin, Wu, Xiaowei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7652321/
https://www.ncbi.nlm.nih.gov/pubmed/33166991
http://dx.doi.org/10.1371/journal.pone.0242045
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author Huang, Yongsheng
Lyu, Xiaoyu
Li, Dan
Wang, Lin
Wang, Yujun
Zou, Wenbin
Wei, Yingxin
Wu, Xiaowei
author_facet Huang, Yongsheng
Lyu, Xiaoyu
Li, Dan
Wang, Lin
Wang, Yujun
Zou, Wenbin
Wei, Yingxin
Wu, Xiaowei
author_sort Huang, Yongsheng
collection PubMed
description Coronavirus Disease 2019 (COVID-19) has recently become a public emergency and a worldwide pandemic. However, the information on the risk factors associated with the mortality of COVID-19 and of their prognostic potential is limited. In this retrospective study, the clinical characteristics, treatment and outcome data were collected and analyzed from 676 COVID-19 patients stratified into 140 non-survivors and 536 survivors. We found that the levels of Dimerized plasmin fragment D (D-dimer), C-reactive protein (CRP), lactate dehydrogenase (LDH), procalcitonin (PCT) were significantly higher in non-survivals on admission (non-survivors vs. survivors: D-Dimer ≥ 0.5 mg/L, 83.2% vs. 44.9%, P<0.01; CRP ≥10 mg/L, 50.4% vs. 6.0%, P<0.01; LDH ≥ 250 U/L, 73.8% vs. 20.1%, P<0.01; PCT ≥ 0.5 ng/ml, 27.7% vs. 1.8%, P<0.01). Moreover, dynamic tracking showed D-dimer kept increasing in non-survivors, while CRP, LDH and PCT remained relatively stable after admission. D-dimer has the highest C-index to predict in-hospital mortality, and patients with D-dimer levels ≥0.5 mg/L had a higher incidence of mortality (Hazard Ratio: 4.39, P<0.01). Our study suggested D-dimer could be a potent marker to predict the mortality of COVID-19, which may be helpful for the management of patients.
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spelling pubmed-76523212020-11-18 A cohort study of 676 patients indicates D-dimer is a critical risk factor for the mortality of COVID-19 Huang, Yongsheng Lyu, Xiaoyu Li, Dan Wang, Lin Wang, Yujun Zou, Wenbin Wei, Yingxin Wu, Xiaowei PLoS One Research Article Coronavirus Disease 2019 (COVID-19) has recently become a public emergency and a worldwide pandemic. However, the information on the risk factors associated with the mortality of COVID-19 and of their prognostic potential is limited. In this retrospective study, the clinical characteristics, treatment and outcome data were collected and analyzed from 676 COVID-19 patients stratified into 140 non-survivors and 536 survivors. We found that the levels of Dimerized plasmin fragment D (D-dimer), C-reactive protein (CRP), lactate dehydrogenase (LDH), procalcitonin (PCT) were significantly higher in non-survivals on admission (non-survivors vs. survivors: D-Dimer ≥ 0.5 mg/L, 83.2% vs. 44.9%, P<0.01; CRP ≥10 mg/L, 50.4% vs. 6.0%, P<0.01; LDH ≥ 250 U/L, 73.8% vs. 20.1%, P<0.01; PCT ≥ 0.5 ng/ml, 27.7% vs. 1.8%, P<0.01). Moreover, dynamic tracking showed D-dimer kept increasing in non-survivors, while CRP, LDH and PCT remained relatively stable after admission. D-dimer has the highest C-index to predict in-hospital mortality, and patients with D-dimer levels ≥0.5 mg/L had a higher incidence of mortality (Hazard Ratio: 4.39, P<0.01). Our study suggested D-dimer could be a potent marker to predict the mortality of COVID-19, which may be helpful for the management of patients. Public Library of Science 2020-11-09 /pmc/articles/PMC7652321/ /pubmed/33166991 http://dx.doi.org/10.1371/journal.pone.0242045 Text en © 2020 Huang et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Huang, Yongsheng
Lyu, Xiaoyu
Li, Dan
Wang, Lin
Wang, Yujun
Zou, Wenbin
Wei, Yingxin
Wu, Xiaowei
A cohort study of 676 patients indicates D-dimer is a critical risk factor for the mortality of COVID-19
title A cohort study of 676 patients indicates D-dimer is a critical risk factor for the mortality of COVID-19
title_full A cohort study of 676 patients indicates D-dimer is a critical risk factor for the mortality of COVID-19
title_fullStr A cohort study of 676 patients indicates D-dimer is a critical risk factor for the mortality of COVID-19
title_full_unstemmed A cohort study of 676 patients indicates D-dimer is a critical risk factor for the mortality of COVID-19
title_short A cohort study of 676 patients indicates D-dimer is a critical risk factor for the mortality of COVID-19
title_sort cohort study of 676 patients indicates d-dimer is a critical risk factor for the mortality of covid-19
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7652321/
https://www.ncbi.nlm.nih.gov/pubmed/33166991
http://dx.doi.org/10.1371/journal.pone.0242045
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