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ACE2: Evidence of role as entry receptor for SARS-CoV-2 and implications in comorbidities

Pandemic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus 19 disease (COVID-19) which presents a large spectrum of manifestations with fatal outcomes in vulnerable people over 70-years-old and with hypertension, diabetes, obesity, cardiovascular disease, COPD, and smok...

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Autores principales: Zamorano Cuervo, Natalia, Grandvaux, Nathalie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7652413/
https://www.ncbi.nlm.nih.gov/pubmed/33164751
http://dx.doi.org/10.7554/eLife.61390
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author Zamorano Cuervo, Natalia
Grandvaux, Nathalie
author_facet Zamorano Cuervo, Natalia
Grandvaux, Nathalie
author_sort Zamorano Cuervo, Natalia
collection PubMed
description Pandemic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus 19 disease (COVID-19) which presents a large spectrum of manifestations with fatal outcomes in vulnerable people over 70-years-old and with hypertension, diabetes, obesity, cardiovascular disease, COPD, and smoking status. Knowledge of the entry receptor is key to understand SARS-CoV-2 tropism, transmission and pathogenesis. Early evidence pointed to angiotensin-converting enzyme 2 (ACE2) as SARS-CoV-2 entry receptor. Here, we provide a critical summary of the current knowledge highlighting the limitations and remaining gaps that need to be addressed to fully characterize ACE2 function in SARS-CoV-2 infection and associated pathogenesis. We also discuss ACE2 expression and potential role in the context of comorbidities associated with poor COVID-19 outcomes. Finally, we discuss the potential co-receptors/attachment factors such as neuropilins, heparan sulfate and sialic acids and the putative alternative receptors, such as CD147 and GRP78.
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spelling pubmed-76524132020-11-12 ACE2: Evidence of role as entry receptor for SARS-CoV-2 and implications in comorbidities Zamorano Cuervo, Natalia Grandvaux, Nathalie eLife Cell Biology Pandemic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus 19 disease (COVID-19) which presents a large spectrum of manifestations with fatal outcomes in vulnerable people over 70-years-old and with hypertension, diabetes, obesity, cardiovascular disease, COPD, and smoking status. Knowledge of the entry receptor is key to understand SARS-CoV-2 tropism, transmission and pathogenesis. Early evidence pointed to angiotensin-converting enzyme 2 (ACE2) as SARS-CoV-2 entry receptor. Here, we provide a critical summary of the current knowledge highlighting the limitations and remaining gaps that need to be addressed to fully characterize ACE2 function in SARS-CoV-2 infection and associated pathogenesis. We also discuss ACE2 expression and potential role in the context of comorbidities associated with poor COVID-19 outcomes. Finally, we discuss the potential co-receptors/attachment factors such as neuropilins, heparan sulfate and sialic acids and the putative alternative receptors, such as CD147 and GRP78. eLife Sciences Publications, Ltd 2020-11-09 /pmc/articles/PMC7652413/ /pubmed/33164751 http://dx.doi.org/10.7554/eLife.61390 Text en © 2020, Zamorano Cuervo and Grandvaux http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Cell Biology
Zamorano Cuervo, Natalia
Grandvaux, Nathalie
ACE2: Evidence of role as entry receptor for SARS-CoV-2 and implications in comorbidities
title ACE2: Evidence of role as entry receptor for SARS-CoV-2 and implications in comorbidities
title_full ACE2: Evidence of role as entry receptor for SARS-CoV-2 and implications in comorbidities
title_fullStr ACE2: Evidence of role as entry receptor for SARS-CoV-2 and implications in comorbidities
title_full_unstemmed ACE2: Evidence of role as entry receptor for SARS-CoV-2 and implications in comorbidities
title_short ACE2: Evidence of role as entry receptor for SARS-CoV-2 and implications in comorbidities
title_sort ace2: evidence of role as entry receptor for sars-cov-2 and implications in comorbidities
topic Cell Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7652413/
https://www.ncbi.nlm.nih.gov/pubmed/33164751
http://dx.doi.org/10.7554/eLife.61390
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