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Cardiac damage in patients with the severe type of coronavirus disease 2019 (COVID-19)
BACKGROUND: Coronavirus disease 2019 (COVID-19) has become a global pandemic. Studies showed COVID-19 affected not only the lung but also other organs. In this study, we aimed to explore the cardiac damage in patients with COVID-19. METHODS: We collected data of 100 patients diagnosed as severe type...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7652577/ https://www.ncbi.nlm.nih.gov/pubmed/33167876 http://dx.doi.org/10.1186/s12872-020-01758-w |
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author | Li, Jing Zhang, Yinghua Wang, Fang Liu, Bing Li, Hui Tang, Guodong Chang, Zhigang Liu, Aihua Fu, Chunyi Lv, You Gao, Jing Li, Jing |
author_facet | Li, Jing Zhang, Yinghua Wang, Fang Liu, Bing Li, Hui Tang, Guodong Chang, Zhigang Liu, Aihua Fu, Chunyi Lv, You Gao, Jing Li, Jing |
author_sort | Li, Jing |
collection | PubMed |
description | BACKGROUND: Coronavirus disease 2019 (COVID-19) has become a global pandemic. Studies showed COVID-19 affected not only the lung but also other organs. In this study, we aimed to explore the cardiac damage in patients with COVID-19. METHODS: We collected data of 100 patients diagnosed as severe type of COVID-19 from February 8 to April 10, 2020, including demographics, illness history, physical examination, laboratory test, and treatment. In-hospital mortality were observed. Cardiac damage was defined as plasma hypersensitive troponin I (hsTnI) over 34.2 pg/ml and/or N-terminal-pro brain natriuretic peptide (NTproBNP) above 450 pg/ml at the age < 50, above 900 pg/ml at the age < 75, or above 1800 pg/ml at the age ≥ 75. RESULTS: The median age of the patients was 62.0 years old. 69 (69.0%) had comorbidities, mainly presenting hypertension, diabetes, and cardiovascular disease. Fever (69 [69.0%]), cough (63 [63.0%]), chest distress (13 [13.0%]), and fatigue (12 [12.0%]) were the common initial symptoms. Cardiac damage occurred in 25 patients. In the subgroups, hsTnI was significantly higher in elder patients (≥ 60 years) than in the young (median [IQR], 5.2 [2.2–12.8] vs. 1.9 [1.9–6.2], p = 0.018) and was higher in men than in women (4.2 [1.9–12.8] vs. 2.9 [1.9–7.4], p = 0.018). The prevalence of increased NTproBNP was significantly higher in men than in women (32.1% vs. 9.1%, p = 0.006), but was similar between the elder and young patients (20.0% vs. 25.0%, p = 0.554). After multivariable analysis, male and hypertension were the risk factors of cardiac damage. The mortality was 4.0%. CONCLUSIONS: Cardiac damage exists in patients with the severe type of COVID-19, especially in male patients with hypertension. Clinicians should pay more attention to cardiac damage. |
format | Online Article Text |
id | pubmed-7652577 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-76525772020-11-10 Cardiac damage in patients with the severe type of coronavirus disease 2019 (COVID-19) Li, Jing Zhang, Yinghua Wang, Fang Liu, Bing Li, Hui Tang, Guodong Chang, Zhigang Liu, Aihua Fu, Chunyi Lv, You Gao, Jing Li, Jing BMC Cardiovasc Disord Research Article BACKGROUND: Coronavirus disease 2019 (COVID-19) has become a global pandemic. Studies showed COVID-19 affected not only the lung but also other organs. In this study, we aimed to explore the cardiac damage in patients with COVID-19. METHODS: We collected data of 100 patients diagnosed as severe type of COVID-19 from February 8 to April 10, 2020, including demographics, illness history, physical examination, laboratory test, and treatment. In-hospital mortality were observed. Cardiac damage was defined as plasma hypersensitive troponin I (hsTnI) over 34.2 pg/ml and/or N-terminal-pro brain natriuretic peptide (NTproBNP) above 450 pg/ml at the age < 50, above 900 pg/ml at the age < 75, or above 1800 pg/ml at the age ≥ 75. RESULTS: The median age of the patients was 62.0 years old. 69 (69.0%) had comorbidities, mainly presenting hypertension, diabetes, and cardiovascular disease. Fever (69 [69.0%]), cough (63 [63.0%]), chest distress (13 [13.0%]), and fatigue (12 [12.0%]) were the common initial symptoms. Cardiac damage occurred in 25 patients. In the subgroups, hsTnI was significantly higher in elder patients (≥ 60 years) than in the young (median [IQR], 5.2 [2.2–12.8] vs. 1.9 [1.9–6.2], p = 0.018) and was higher in men than in women (4.2 [1.9–12.8] vs. 2.9 [1.9–7.4], p = 0.018). The prevalence of increased NTproBNP was significantly higher in men than in women (32.1% vs. 9.1%, p = 0.006), but was similar between the elder and young patients (20.0% vs. 25.0%, p = 0.554). After multivariable analysis, male and hypertension were the risk factors of cardiac damage. The mortality was 4.0%. CONCLUSIONS: Cardiac damage exists in patients with the severe type of COVID-19, especially in male patients with hypertension. Clinicians should pay more attention to cardiac damage. BioMed Central 2020-11-10 /pmc/articles/PMC7652577/ /pubmed/33167876 http://dx.doi.org/10.1186/s12872-020-01758-w Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Article Li, Jing Zhang, Yinghua Wang, Fang Liu, Bing Li, Hui Tang, Guodong Chang, Zhigang Liu, Aihua Fu, Chunyi Lv, You Gao, Jing Li, Jing Cardiac damage in patients with the severe type of coronavirus disease 2019 (COVID-19) |
title | Cardiac damage in patients with the severe type of coronavirus disease 2019 (COVID-19) |
title_full | Cardiac damage in patients with the severe type of coronavirus disease 2019 (COVID-19) |
title_fullStr | Cardiac damage in patients with the severe type of coronavirus disease 2019 (COVID-19) |
title_full_unstemmed | Cardiac damage in patients with the severe type of coronavirus disease 2019 (COVID-19) |
title_short | Cardiac damage in patients with the severe type of coronavirus disease 2019 (COVID-19) |
title_sort | cardiac damage in patients with the severe type of coronavirus disease 2019 (covid-19) |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7652577/ https://www.ncbi.nlm.nih.gov/pubmed/33167876 http://dx.doi.org/10.1186/s12872-020-01758-w |
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