SARS-CoV-2 and interferon blockade

The response to viral infection generally includes an activation of the adaptive immune response to produce cytotoxic T cells and neutralizing antibodies. We propose that SARS-CoV-2 activates the innate immune system through the renin-angiotensin and kallikrein-bradykinin pathways, blocks interferon...

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Detalles Bibliográficos
Autores principales: Diamond, Betty, Volpe, Bruce T., VanPatten, Sonya, Al Abed, Yousef
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7652589/
https://www.ncbi.nlm.nih.gov/pubmed/33167852
http://dx.doi.org/10.1186/s10020-020-00231-w
Descripción
Sumario:The response to viral infection generally includes an activation of the adaptive immune response to produce cytotoxic T cells and neutralizing antibodies. We propose that SARS-CoV-2 activates the innate immune system through the renin-angiotensin and kallikrein-bradykinin pathways, blocks interferon production and reduces an effective adaptive immune response. This model has therapeutic implications.

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