Cargando…
Factors associated with phylogenetic clustering of hepatitis C among people who inject drugs in Baltimore
BACKGROUND: The availability of effective, oral direct acting antivirals (DAAs) for hepatitis C virus (HCV) treatment has put elimination of HCV as a public health challenge within reach. However, little is known about the characteristics of transmission networks of people who inject drugs (PWID). M...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7652590/ https://www.ncbi.nlm.nih.gov/pubmed/33167892 http://dx.doi.org/10.1186/s12879-020-05546-x |
_version_ | 1783607720958492672 |
---|---|
author | Falade-Nwulia, Oluwaseun Hackman, Jada Mehta, Shruti H. McCormick, Sean D. Kirk, Gregory D. Sulkowski, Mark Thomas, David Latkin, Carl Laeyendecker, Oliver Ray, Stuart C. |
author_facet | Falade-Nwulia, Oluwaseun Hackman, Jada Mehta, Shruti H. McCormick, Sean D. Kirk, Gregory D. Sulkowski, Mark Thomas, David Latkin, Carl Laeyendecker, Oliver Ray, Stuart C. |
author_sort | Falade-Nwulia, Oluwaseun |
collection | PubMed |
description | BACKGROUND: The availability of effective, oral direct acting antivirals (DAAs) for hepatitis C virus (HCV) treatment has put elimination of HCV as a public health challenge within reach. However, little is known about the characteristics of transmission networks of people who inject drugs (PWID). METHODS: Sequencing of a segment of the HCV genome was performed on samples collected from a community-based cohort of PWID between August 2005 and December 2016. Phylogenetic trees were inferred, and clusters were identified (70% bootstrap threshold; 0.04 maximum genetic distance threshold). We describe sex, race, age difference, and HIV infection status of potential transmission partners. Logistic regression was used to assess factors associated with being in an HCV cluster. RESULTS: Of 508 HCV genotype 1 viremic PWID, 8% (n = 41) were grouped into 20 clusters, consisting of 19 pairs and 1 triad. In adjusted analyses, female sex (odds ratio [OR] 2.3 [95% confidence interval (CI) 1.2–4.5]) and HIV infection (OR 5.7 [CI 2.7–11.9]) remained independently associated with being in an HCV infection cluster. CONCLUSIONS: Molecular epidemiological analysis reveals that, in this cohort of PWID in Baltimore, HIV infection and female sex were associated with HCV clustering. Combination HCV prevention interventions targeting HIV infected PWID and addressing HCV infection prevention needs of women have potential to advance HCV elimination efforts. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12879-020-05546-x. |
format | Online Article Text |
id | pubmed-7652590 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-76525902020-11-10 Factors associated with phylogenetic clustering of hepatitis C among people who inject drugs in Baltimore Falade-Nwulia, Oluwaseun Hackman, Jada Mehta, Shruti H. McCormick, Sean D. Kirk, Gregory D. Sulkowski, Mark Thomas, David Latkin, Carl Laeyendecker, Oliver Ray, Stuart C. BMC Infect Dis Research Article BACKGROUND: The availability of effective, oral direct acting antivirals (DAAs) for hepatitis C virus (HCV) treatment has put elimination of HCV as a public health challenge within reach. However, little is known about the characteristics of transmission networks of people who inject drugs (PWID). METHODS: Sequencing of a segment of the HCV genome was performed on samples collected from a community-based cohort of PWID between August 2005 and December 2016. Phylogenetic trees were inferred, and clusters were identified (70% bootstrap threshold; 0.04 maximum genetic distance threshold). We describe sex, race, age difference, and HIV infection status of potential transmission partners. Logistic regression was used to assess factors associated with being in an HCV cluster. RESULTS: Of 508 HCV genotype 1 viremic PWID, 8% (n = 41) were grouped into 20 clusters, consisting of 19 pairs and 1 triad. In adjusted analyses, female sex (odds ratio [OR] 2.3 [95% confidence interval (CI) 1.2–4.5]) and HIV infection (OR 5.7 [CI 2.7–11.9]) remained independently associated with being in an HCV infection cluster. CONCLUSIONS: Molecular epidemiological analysis reveals that, in this cohort of PWID in Baltimore, HIV infection and female sex were associated with HCV clustering. Combination HCV prevention interventions targeting HIV infected PWID and addressing HCV infection prevention needs of women have potential to advance HCV elimination efforts. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12879-020-05546-x. BioMed Central 2020-11-10 /pmc/articles/PMC7652590/ /pubmed/33167892 http://dx.doi.org/10.1186/s12879-020-05546-x Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Article Falade-Nwulia, Oluwaseun Hackman, Jada Mehta, Shruti H. McCormick, Sean D. Kirk, Gregory D. Sulkowski, Mark Thomas, David Latkin, Carl Laeyendecker, Oliver Ray, Stuart C. Factors associated with phylogenetic clustering of hepatitis C among people who inject drugs in Baltimore |
title | Factors associated with phylogenetic clustering of hepatitis C among people who inject drugs in Baltimore |
title_full | Factors associated with phylogenetic clustering of hepatitis C among people who inject drugs in Baltimore |
title_fullStr | Factors associated with phylogenetic clustering of hepatitis C among people who inject drugs in Baltimore |
title_full_unstemmed | Factors associated with phylogenetic clustering of hepatitis C among people who inject drugs in Baltimore |
title_short | Factors associated with phylogenetic clustering of hepatitis C among people who inject drugs in Baltimore |
title_sort | factors associated with phylogenetic clustering of hepatitis c among people who inject drugs in baltimore |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7652590/ https://www.ncbi.nlm.nih.gov/pubmed/33167892 http://dx.doi.org/10.1186/s12879-020-05546-x |
work_keys_str_mv | AT faladenwuliaoluwaseun factorsassociatedwithphylogeneticclusteringofhepatitiscamongpeoplewhoinjectdrugsinbaltimore AT hackmanjada factorsassociatedwithphylogeneticclusteringofhepatitiscamongpeoplewhoinjectdrugsinbaltimore AT mehtashrutih factorsassociatedwithphylogeneticclusteringofhepatitiscamongpeoplewhoinjectdrugsinbaltimore AT mccormickseand factorsassociatedwithphylogeneticclusteringofhepatitiscamongpeoplewhoinjectdrugsinbaltimore AT kirkgregoryd factorsassociatedwithphylogeneticclusteringofhepatitiscamongpeoplewhoinjectdrugsinbaltimore AT sulkowskimark factorsassociatedwithphylogeneticclusteringofhepatitiscamongpeoplewhoinjectdrugsinbaltimore AT thomasdavid factorsassociatedwithphylogeneticclusteringofhepatitiscamongpeoplewhoinjectdrugsinbaltimore AT latkincarl factorsassociatedwithphylogeneticclusteringofhepatitiscamongpeoplewhoinjectdrugsinbaltimore AT laeyendeckeroliver factorsassociatedwithphylogeneticclusteringofhepatitiscamongpeoplewhoinjectdrugsinbaltimore AT raystuartc factorsassociatedwithphylogeneticclusteringofhepatitiscamongpeoplewhoinjectdrugsinbaltimore |