Somatic copy number gains in MYC, BCL2, and BCL6 identifies a subset of aggressive alternative-DH/TH DLBCL patients

Double/triple hit lymphoma (DH/TH), known as high-grade B-cell lymphoma (HGBL), is an aggressive diffuse large B cell lymphoma (DLBCL), defined as having concurrent MYC, BCL2, and/or BCL6 gene rearrangements. While gene rearrangements represent significant genetic events in cancer, copy number alter...

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Autores principales: Krull, Jordan E., Wenzl, Kerstin, Hartert, Keenan T., Manske, Michelle K., Sarangi, Vivekananda, Maurer, Matthew J., Larson, Melissa C., Nowakowski, Grzegorz S., Ansell, Stephen M., McPhail, Ellen, Habermann, Thomas M., Link, Brian K., King, Rebecca L., Cerhan, James R., Novak, Anne J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7652824/
https://www.ncbi.nlm.nih.gov/pubmed/33168821
http://dx.doi.org/10.1038/s41408-020-00382-3
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author Krull, Jordan E.
Wenzl, Kerstin
Hartert, Keenan T.
Manske, Michelle K.
Sarangi, Vivekananda
Maurer, Matthew J.
Larson, Melissa C.
Nowakowski, Grzegorz S.
Ansell, Stephen M.
McPhail, Ellen
Habermann, Thomas M.
Link, Brian K.
King, Rebecca L.
Cerhan, James R.
Novak, Anne J.
author_facet Krull, Jordan E.
Wenzl, Kerstin
Hartert, Keenan T.
Manske, Michelle K.
Sarangi, Vivekananda
Maurer, Matthew J.
Larson, Melissa C.
Nowakowski, Grzegorz S.
Ansell, Stephen M.
McPhail, Ellen
Habermann, Thomas M.
Link, Brian K.
King, Rebecca L.
Cerhan, James R.
Novak, Anne J.
author_sort Krull, Jordan E.
collection PubMed
description Double/triple hit lymphoma (DH/TH), known as high-grade B-cell lymphoma (HGBL), is an aggressive diffuse large B cell lymphoma (DLBCL), defined as having concurrent MYC, BCL2, and/or BCL6 gene rearrangements. While gene rearrangements represent significant genetic events in cancer, copy number alterations (CNAs) also play an important role, and their contributions to rearrangements have yet to be fully elucidated. Using FISH and high-resolution CNA data, we defined the landscape of concurrent gene rearrangements and copy gains in MYC, BCL2, and BCL6, in a cohort of 479 newly diagnosed DLBCL. We also show that concurrent translocations and copy number alterations, in combinations similar to DH/TH, identify a unique subset of DLBCL, alternative DH/TH, that have survival outcomes similar to DH/TH DLBCL patients.
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spelling pubmed-76528242020-11-12 Somatic copy number gains in MYC, BCL2, and BCL6 identifies a subset of aggressive alternative-DH/TH DLBCL patients Krull, Jordan E. Wenzl, Kerstin Hartert, Keenan T. Manske, Michelle K. Sarangi, Vivekananda Maurer, Matthew J. Larson, Melissa C. Nowakowski, Grzegorz S. Ansell, Stephen M. McPhail, Ellen Habermann, Thomas M. Link, Brian K. King, Rebecca L. Cerhan, James R. Novak, Anne J. Blood Cancer J Article Double/triple hit lymphoma (DH/TH), known as high-grade B-cell lymphoma (HGBL), is an aggressive diffuse large B cell lymphoma (DLBCL), defined as having concurrent MYC, BCL2, and/or BCL6 gene rearrangements. While gene rearrangements represent significant genetic events in cancer, copy number alterations (CNAs) also play an important role, and their contributions to rearrangements have yet to be fully elucidated. Using FISH and high-resolution CNA data, we defined the landscape of concurrent gene rearrangements and copy gains in MYC, BCL2, and BCL6, in a cohort of 479 newly diagnosed DLBCL. We also show that concurrent translocations and copy number alterations, in combinations similar to DH/TH, identify a unique subset of DLBCL, alternative DH/TH, that have survival outcomes similar to DH/TH DLBCL patients. Nature Publishing Group UK 2020-11-09 /pmc/articles/PMC7652824/ /pubmed/33168821 http://dx.doi.org/10.1038/s41408-020-00382-3 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Krull, Jordan E.
Wenzl, Kerstin
Hartert, Keenan T.
Manske, Michelle K.
Sarangi, Vivekananda
Maurer, Matthew J.
Larson, Melissa C.
Nowakowski, Grzegorz S.
Ansell, Stephen M.
McPhail, Ellen
Habermann, Thomas M.
Link, Brian K.
King, Rebecca L.
Cerhan, James R.
Novak, Anne J.
Somatic copy number gains in MYC, BCL2, and BCL6 identifies a subset of aggressive alternative-DH/TH DLBCL patients
title Somatic copy number gains in MYC, BCL2, and BCL6 identifies a subset of aggressive alternative-DH/TH DLBCL patients
title_full Somatic copy number gains in MYC, BCL2, and BCL6 identifies a subset of aggressive alternative-DH/TH DLBCL patients
title_fullStr Somatic copy number gains in MYC, BCL2, and BCL6 identifies a subset of aggressive alternative-DH/TH DLBCL patients
title_full_unstemmed Somatic copy number gains in MYC, BCL2, and BCL6 identifies a subset of aggressive alternative-DH/TH DLBCL patients
title_short Somatic copy number gains in MYC, BCL2, and BCL6 identifies a subset of aggressive alternative-DH/TH DLBCL patients
title_sort somatic copy number gains in myc, bcl2, and bcl6 identifies a subset of aggressive alternative-dh/th dlbcl patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7652824/
https://www.ncbi.nlm.nih.gov/pubmed/33168821
http://dx.doi.org/10.1038/s41408-020-00382-3
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