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A novel screening method for pediatric urinary tract infection using ordinary diapers

Urinary tract infection (UTI) is one of the most common bacterial infections in children. The symptoms of UTI in young children are nonspecific, therefore urine should be examined whenever UTI cannot be ruled out. In clinical settings, however, collecting urine from children who are not toilet train...

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Autores principales: Ohnishi, Takuma, Asada, Nariaki, Furuichi, Munehiro, Sekiguchi, Shinichiro, Awazu, Midori, Hori, Naoaki, Kamimaki, Isamu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7652829/
https://www.ncbi.nlm.nih.gov/pubmed/33168907
http://dx.doi.org/10.1038/s41598-020-76405-7
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author Ohnishi, Takuma
Asada, Nariaki
Furuichi, Munehiro
Sekiguchi, Shinichiro
Awazu, Midori
Hori, Naoaki
Kamimaki, Isamu
author_facet Ohnishi, Takuma
Asada, Nariaki
Furuichi, Munehiro
Sekiguchi, Shinichiro
Awazu, Midori
Hori, Naoaki
Kamimaki, Isamu
author_sort Ohnishi, Takuma
collection PubMed
description Urinary tract infection (UTI) is one of the most common bacterial infections in children. The symptoms of UTI in young children are nonspecific, therefore urine should be examined whenever UTI cannot be ruled out. In clinical settings, however, collecting urine from children who are not toilet trained is sometimes difficult, presenting a challenge in UTI management. Here, we developed a “diaper UTI test”, which enables the quick detection of pyuria in ordinary diapers, and investigated its sensitivity and specificity in a clinical study. The diaper UTI test is based on a leukocyte esterase reaction. Reagent was prepared in liquid form so that it can be absorbed by disposable diapers, where it will produce a violet color in the presence of pyuria. For the clinical study, we enrolled children younger than 3 years with potential UTI who underwent bladder catheterization for urine culture and urinalysis. Of the 65 children included, 21 were diagnosed with UTI. The sensitivity and specificity of the diaper UTI test were 90.5% (95% CI 69.6–98.8) and 93.2% (95% CI 81.3–98.6), respectively. Because of its convenience and good sensitivity, the diaper UTI test may be useful in the screening of pediatric UTI.
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spelling pubmed-76528292020-11-12 A novel screening method for pediatric urinary tract infection using ordinary diapers Ohnishi, Takuma Asada, Nariaki Furuichi, Munehiro Sekiguchi, Shinichiro Awazu, Midori Hori, Naoaki Kamimaki, Isamu Sci Rep Article Urinary tract infection (UTI) is one of the most common bacterial infections in children. The symptoms of UTI in young children are nonspecific, therefore urine should be examined whenever UTI cannot be ruled out. In clinical settings, however, collecting urine from children who are not toilet trained is sometimes difficult, presenting a challenge in UTI management. Here, we developed a “diaper UTI test”, which enables the quick detection of pyuria in ordinary diapers, and investigated its sensitivity and specificity in a clinical study. The diaper UTI test is based on a leukocyte esterase reaction. Reagent was prepared in liquid form so that it can be absorbed by disposable diapers, where it will produce a violet color in the presence of pyuria. For the clinical study, we enrolled children younger than 3 years with potential UTI who underwent bladder catheterization for urine culture and urinalysis. Of the 65 children included, 21 were diagnosed with UTI. The sensitivity and specificity of the diaper UTI test were 90.5% (95% CI 69.6–98.8) and 93.2% (95% CI 81.3–98.6), respectively. Because of its convenience and good sensitivity, the diaper UTI test may be useful in the screening of pediatric UTI. Nature Publishing Group UK 2020-11-09 /pmc/articles/PMC7652829/ /pubmed/33168907 http://dx.doi.org/10.1038/s41598-020-76405-7 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Ohnishi, Takuma
Asada, Nariaki
Furuichi, Munehiro
Sekiguchi, Shinichiro
Awazu, Midori
Hori, Naoaki
Kamimaki, Isamu
A novel screening method for pediatric urinary tract infection using ordinary diapers
title A novel screening method for pediatric urinary tract infection using ordinary diapers
title_full A novel screening method for pediatric urinary tract infection using ordinary diapers
title_fullStr A novel screening method for pediatric urinary tract infection using ordinary diapers
title_full_unstemmed A novel screening method for pediatric urinary tract infection using ordinary diapers
title_short A novel screening method for pediatric urinary tract infection using ordinary diapers
title_sort novel screening method for pediatric urinary tract infection using ordinary diapers
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7652829/
https://www.ncbi.nlm.nih.gov/pubmed/33168907
http://dx.doi.org/10.1038/s41598-020-76405-7
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