Ceramide analog [(18)F]F-HPA-12 detects sphingolipid disbalance in the brain of Alzheimer’s disease transgenic mice by functioning as a metabolic probe

The metabolism of ceramides is deregulated in the brain of Alzheimer’s disease (AD) patients and is associated with apolipoprotein (APO) APOE4 and amyloid-β pathology. However, how the ceramide metabolism changes over time in AD, in vivo, remains unknown. Distribution and metabolism of [(18)F]F-HPA-...

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Detalles Bibliográficos
Autores principales: Crivelli, Simone M., van Kruining, Daan, Luo, Qian, Stevens, Jo A. A., Giovagnoni, Caterina, Paulus, Andreas, Bauwens, Matthias, Berkes, Dusan, de Vries, Helga E., Mulder, Monique T., Walter, Jochen, Waelkens, Etienne, Derua, Rita, Swinnen, Johannes V., Dehairs, Jonas, Mottaghy, Felix M., Losen, Mario, Bieberich, Erhard, Martinez-Martinez, Pilar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7652882/
https://www.ncbi.nlm.nih.gov/pubmed/33168861
http://dx.doi.org/10.1038/s41598-020-76335-4

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