Pre-clinical animal models are poor predictors of human toxicities in phase 1 oncology clinical trials

BACKGROUND: Our objective was to determine the correlation between preclinical toxicity found in animal models (mouse, rat, dog and monkey) and clinical toxicity reported in patients participating in Phase 1 oncology clinical trials. METHODS: We obtained from two major early-Phase clinical trial cen...

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Detalles Bibliográficos
Autores principales: Atkins, Johnique T., George, Goldy C., Hess, Kenneth, Marcelo-Lewis, Kathrina L., Yuan, Ying, Borthakur, Gautam, Khozin, Sean, LoRusso, Patricia, Hong, David S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7652903/
https://www.ncbi.nlm.nih.gov/pubmed/32868897
http://dx.doi.org/10.1038/s41416-020-01033-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7652903/
https://www.ncbi.nlm.nih.gov/pubmed/32868897
http://dx.doi.org/10.1038/s41416-020-01033-x

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