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Pre-clinical animal models are poor predictors of human toxicities in phase 1 oncology clinical trials
BACKGROUND: Our objective was to determine the correlation between preclinical toxicity found in animal models (mouse, rat, dog and monkey) and clinical toxicity reported in patients participating in Phase 1 oncology clinical trials. METHODS: We obtained from two major early-Phase clinical trial cen...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7652903/ https://www.ncbi.nlm.nih.gov/pubmed/32868897 http://dx.doi.org/10.1038/s41416-020-01033-x |