Genomic landscape and clonal architecture of mouse oral squamous cell carcinomas dictate tumour ecology

To establish whether 4-nitroquinoline N-oxide-induced carcinogenesis mirrors the heterogeneity of human oral squamous cell carcinoma (OSCC), we have performed genomic analysis of mouse tongue lesions. The mutational signatures of human and mouse OSCC overlap extensively. Mutational burden is higher...

Descripción completa

Detalles Bibliográficos
Autores principales: Sequeira, Inês, Rashid, Mamunur, Tomás, Inês M., Williams, Marc J., Graham, Trevor A., Adams, David J., Vigilante, Alessandra, Watt, Fiona M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7652942/
https://www.ncbi.nlm.nih.gov/pubmed/33168804
http://dx.doi.org/10.1038/s41467-020-19401-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7652942/
https://www.ncbi.nlm.nih.gov/pubmed/33168804
http://dx.doi.org/10.1038/s41467-020-19401-9

Ejemplares similares