Automated synthesis of (18)F radiolabelled indole containing Oncrasin-like molecules; a comparison of iodonium salts and boronic ester chemistry

BACKGROUND: Oncrasin-1 is a small molecule which was identified from a screen of KRAS mutant cancer cells and has shown specificity for KRAS mutant cell killing. We aimed to develop a radiolabelled form of Oncrasin-1 to enable in-vivo imaging of mutant KRAS expression in malignant tumours. This work...

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Detalles Bibliográficos
Autores principales: McDonald, Alexander F., Goh, Yit Wooi, White, Jonathan M., Scott, Andrew M., Ackermann, Uwe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7652984/
https://www.ncbi.nlm.nih.gov/pubmed/33169204
http://dx.doi.org/10.1186/s41181-020-00104-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7652984/
https://www.ncbi.nlm.nih.gov/pubmed/33169204
http://dx.doi.org/10.1186/s41181-020-00104-x

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