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Bridging Lab and Industry with Flow Electrochemistry

A revitalization of organic electrosynthesis has incited the organic chemistry community to adopt electrochemistry as a green and cost-efficient method for activating small molecules to replace highly toxic and expensive redox chemicals. However, many of the critical challenges of batch electrosynth...

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Detalles Bibliográficos
Autores principales: Tanbouza, Nour, Ollevier, Thierry, Lam, Kevin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7653055/
https://www.ncbi.nlm.nih.gov/pubmed/33205027
http://dx.doi.org/10.1016/j.isci.2020.101720
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author Tanbouza, Nour
Ollevier, Thierry
Lam, Kevin
author_facet Tanbouza, Nour
Ollevier, Thierry
Lam, Kevin
author_sort Tanbouza, Nour
collection PubMed
description A revitalization of organic electrosynthesis has incited the organic chemistry community to adopt electrochemistry as a green and cost-efficient method for activating small molecules to replace highly toxic and expensive redox chemicals. However, many of the critical challenges of batch electrosynthesis, especially for organic synthesis, still remain. The combination of continuous flow technology and electrochemistry is a potent means to enable industry to implement large scale electrosynthesis. Indeed, flow electrosynthesis helps overcome problems that mainly arise from macro batch electro-organic systems, such as mass transfer, ohmic drop, and selectivity, but this is still far from being a flawless and generic applicable process. As a result, a notable increase in research on methodology and hardware sophistication has emerged, and many hitherto uncharted chemistries have been achieved. To better help the commercialization of wide-scale electrification of organic synthesis, we highlight in this perspective the advances made in large-scale flow electrosynthesis and its future trajectory while pointing out the main challenges and key improvements of current methodologies.
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spelling pubmed-76530552020-11-16 Bridging Lab and Industry with Flow Electrochemistry Tanbouza, Nour Ollevier, Thierry Lam, Kevin iScience Perspective A revitalization of organic electrosynthesis has incited the organic chemistry community to adopt electrochemistry as a green and cost-efficient method for activating small molecules to replace highly toxic and expensive redox chemicals. However, many of the critical challenges of batch electrosynthesis, especially for organic synthesis, still remain. The combination of continuous flow technology and electrochemistry is a potent means to enable industry to implement large scale electrosynthesis. Indeed, flow electrosynthesis helps overcome problems that mainly arise from macro batch electro-organic systems, such as mass transfer, ohmic drop, and selectivity, but this is still far from being a flawless and generic applicable process. As a result, a notable increase in research on methodology and hardware sophistication has emerged, and many hitherto uncharted chemistries have been achieved. To better help the commercialization of wide-scale electrification of organic synthesis, we highlight in this perspective the advances made in large-scale flow electrosynthesis and its future trajectory while pointing out the main challenges and key improvements of current methodologies. Elsevier 2020-10-22 /pmc/articles/PMC7653055/ /pubmed/33205027 http://dx.doi.org/10.1016/j.isci.2020.101720 Text en Crown Copyright © 2020. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Perspective
Tanbouza, Nour
Ollevier, Thierry
Lam, Kevin
Bridging Lab and Industry with Flow Electrochemistry
title Bridging Lab and Industry with Flow Electrochemistry
title_full Bridging Lab and Industry with Flow Electrochemistry
title_fullStr Bridging Lab and Industry with Flow Electrochemistry
title_full_unstemmed Bridging Lab and Industry with Flow Electrochemistry
title_short Bridging Lab and Industry with Flow Electrochemistry
title_sort bridging lab and industry with flow electrochemistry
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7653055/
https://www.ncbi.nlm.nih.gov/pubmed/33205027
http://dx.doi.org/10.1016/j.isci.2020.101720
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