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PPARα Ligand-Binding Domain Structures with Endogenous Fatty Acids and Fibrates
Most triacylglycerol-lowering fibrates have been developed in the 1960s–1980s before their molecular target, peroxisome proliferator-activated receptor alpha (PPARα), was identified. Twenty-one ligand-bound PPARα structures have been deposited in the Protein Data Bank since 2001; however, binding mo...
| Autores principales: | , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7653058/ https://www.ncbi.nlm.nih.gov/pubmed/33205029 http://dx.doi.org/10.1016/j.isci.2020.101727 |