Cargando…

ZAP-70 Shapes the Immune Microenvironment in B Cell Malignancies

Zeta-chain-associated protein kinase-70 (ZAP-70) is a tyrosine kinase mainly expressed in T cells, NK cells and a subset of B cells. Primarily it functions in T cell receptor (TCR) activation through its tyrosine kinase activity. Aberrant expression of ZAP-70 has been evidenced in different B cell m...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Jingyu, Moore, Andrew, Ringshausen, Ingo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7653097/ https://www.ncbi.nlm.nih.gov/pubmed/33194762 http://dx.doi.org/10.3389/fonc.2020.595832

Ejemplares similares

Editorial: Tumour microenvironment heterogeneity in hematological malignancies
por: Deaglio, Silvia, et al.
Publicado: (2023)

Reconstitution of T cell receptor signaling in ZAP-70-deficient cells by retroviral transduction of the ZAP-70 gene
Publicado: (1996)

Lck promotes Zap70-dependent LAT phosphorylation by bridging Zap70 to LAT
por: Lo, Wan-Lin, et al.
Publicado: (2018)

Understanding the Immune-Stroma Microenvironment in B Cell Malignancies for Effective Immunotherapy
por: Apollonio, Benedetta, et al.
Publicado: (2021)

Dephosphorylation accelerates the dissociation of ZAP70 from the T cell receptor
por: Goyette, Jesse, et al.
Publicado: (2022)

ZAP-70 Restoration in Mice by In Vivo Thymic Electroporation
por: Irla, Magali, et al.
Publicado: (2008)

T cell receptor–dependent S-acylation of ZAP-70 controls activation of T cells
por: Tewari, Ritika, et al.
Publicado: (2021)

Otud7b facilitates T cell activation and inflammatory responses by regulating Zap70 ubiquitination
por: Hu, Hongbo, et al.
Publicado: (2016)

Immune Microenvironment and Genetics in Malignant Pleural Mesothelioma
por: Wadowski, Benjamin, et al.
Publicado: (2021)

The Structural Basis for Activation and Inhibition of ZAP-70 Kinase Domain
por: Huber, Roland G., et al.
Publicado: (2015)

Self-Shielding Analysis of the Zap-X System
por: Weidlich, Georg A., et al.
Publicado: (2017)

T and NK cell lymphoma cell lines do not rely on ZAP-70 for survival
por: de Mel, Sanjay, et al.
Publicado: (2022)

ZAP-70 Promotes the Infiltration of Malignant B-Lymphocytes into the Bone Marrow by Enhancing Signaling and Migration after CXCR4 Stimulation
por: Calpe, Eva, et al.
Publicado: (2013)

Bone Marrow Stromal Cells Drive Key Hallmarks of B Cell Malignancies
por: Mangolini, Maurizio, et al.
Publicado: (2020)

ZAP-70 Tyrosine Kinase Is Required for LFA-1–dependent T Cell Migration
por: Soede, Ron D.M., et al.
Publicado: (1998)

Engineering a Dual Small Molecule Gated ZAP70 Switch in T Cells
por: Wong, Nicole M. L., et al.
Publicado: (2018)

ZAP-70 Regulates Autoimmune Arthritis via Alterations in T Cell Activation and Apoptosis
por: Kugyelka, Réka, et al.
Publicado: (2019)

Intrinsic Disorder in the T Cell Receptor Creates Cooperativity and Controls ZAP70 Binding
por: Clemens, Lara, et al.
Publicado: (2021)

Immune synapse formation requires ZAP-70 recruitment by ezrin and CD43 removal by moesin
por: Ilani, Tal, et al.
Publicado: (2007)

Gefitinib targets ZAP-70-expressing chronic lymphocytic leukemia cells and inhibits B-cell receptor signaling
por: Dielschneider, R F, et al.
Publicado: (2014)

Distinct roles for Syk and ZAP-70 during early thymocyte development
por: Palacios, Emil H., et al.
Publicado: (2007)

Regulation of ZAP-70 Intracellular Localization: Visualization with the Green Fluorescent Protein
por: Sloan-Lancaster, Joanne, et al.
Publicado: (1997)

Increased ZAP70 Is Involved in Dry Skin Pruritus in Aged Mice
por: Zhao, Nan, et al.
Publicado: (2016)

Cytokine Contents in Chronic Lymphocytic Leukemia: Association with ZAP70 Expression
por: Işıksaçan, Nilgün, et al.
Publicado: (2016)

ZAP70, too little, too much can lead to autoimmunity
por: Ashouri, Judith F., et al.
Publicado: (2021)

Bone Marrow Senescence and the Microenvironment of Hematological Malignancies
por: Hellmich, Charlotte, et al.
Publicado: (2020)

AQP9 and ZAP70 as immune-related prognostic biomarkers suppress proliferation, migration and invasion of laryngeal cancer cells
por: Ren, Li, et al.
Publicado: (2022)

GTPase-activating protein Rasal1 associates with ZAP-70 of the TCR and negatively regulates T-cell tumor immunity
por: Thaker, Youg Raj, et al.
Publicado: (2019)

ZAP-70 binding specificity to T cell receptor tyrosine-based activation motifs: the tandem SH2 domains of ZAP-70 bind distinct tyrosine-based activation motifs with varying affinity
Publicado: (1995)

High CD74 expression correlates with ZAP70 expression in B cell chronic lymphocytic leukemia patients
por: Butrym, Aleksandra, et al.
Publicado: (2013)

Combined analysis of ZAP-70 and CD38 expression in sudanese patients with B-cell chronic lymphocytic leukemia
por: Basabaeen, Ameen Abdulaziz, et al.
Publicado: (2019)

Eph receptor B6 shapes a cold immune microenvironment, inhibiting anti-cancer immunity and immunotherapy response in bladder cancer
por: Jia, Xiaolong, et al.
Publicado: (2023)

Lck regulates the tyrosine phosphorylation of the T cell receptor subunits and ZAP-70 in murine thymocytes
Publicado: (1996)

RhoH Regulates Subcellular Localization of ZAP-70 and Lck in T Cell Receptor Signaling
por: Chae, Hee-Don, et al.
Publicado: (2010)

Quantitative and Temporal Requirements Revealed for Zap-70 Catalytic Activity During T Cell Development
por: Au-Yeung, Byron B., et al.
Publicado: (2014)

An evolutionary divergent thermodynamic brake in ZAP-70 fine-tunes the kinetic proofreading in T cells
por: Gangopadhyay, Kaustav, et al.
Publicado: (2022)

Destabilizing the autoinhibitory conformation of Zap70 induces up-regulation of inhibitory receptors and T cell unresponsiveness
por: Hsu, Lih-Yun, et al.
Publicado: (2017)

Glioma-Associated Stromal Cells Stimulate Glioma Malignancy by Regulating the Tumor Immune Microenvironment
por: Cai, Xiangming, et al.
Publicado: (2021)

Distinct structural and catalytic roles for Zap70 in formation of the immunological synapse in CTL
por: Jenkins, Misty R, et al.
Publicado: (2014)

Morpholino-based correction of hypomorphic ZAP70 mutation in an adult with combined immunodeficiency
por: Gavino, Christina, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_afekmerb779456931iv4fcg0jp