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Low T790M relative allele frequency indicates concurrent resistance mechanisms and poor responsiveness to osimertinib

BACKGROUND: T790M relative allele frequency (RAF) in plasma, calculated by the ratio of T790M to epidermal growth factor receptor (EGFR)-sensitizing mutation allele frequencies (AF), is associated with osimertinib response in patients with progressive non-small cell lung cancer (NSCLC) post 1(st) ge...

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Detalles Bibliográficos
Autores principales:	Wang, Ye, He, Yanqi, Tian, Panwen, Wang, Weiya, Wang, Ke, Chuai, Shannon, Li, Yalun, Zhao, Shuang, Wang, Yu, Li, Weimin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	AME Publishing Company 2020
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7653156/ https://www.ncbi.nlm.nih.gov/pubmed/33209615 http://dx.doi.org/10.21037/tlcr-20-915

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