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Fatal COVID‐19 infection in a patient with long‐chain 3‐hydroxyacyl‐CoA dehydrogenase deficiency: A case report

Long‐chain fatty‐acyl CoA dehydrogenase deficiency (LCHADD) is an inborn error of long chain fatty acid oxidation with various features including hypoketotic hypoglycemia, recurrent rhabdomyolysis, pigmentary retinopathy, peripheral neuropathy, cardiomyopathy, and arrhythmias. Various stresses trigg...

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Autores principales: Wongkittichote, Parith, Watson, James R., Leonard, Jennifer M., Toolan, Elizabeth R., Dickson, Patricia I., Grange, Dorothy K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7653242/
https://www.ncbi.nlm.nih.gov/pubmed/33204595
http://dx.doi.org/10.1002/jmd2.12165
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author Wongkittichote, Parith
Watson, James R.
Leonard, Jennifer M.
Toolan, Elizabeth R.
Dickson, Patricia I.
Grange, Dorothy K.
author_facet Wongkittichote, Parith
Watson, James R.
Leonard, Jennifer M.
Toolan, Elizabeth R.
Dickson, Patricia I.
Grange, Dorothy K.
author_sort Wongkittichote, Parith
collection PubMed
description Long‐chain fatty‐acyl CoA dehydrogenase deficiency (LCHADD) is an inborn error of long chain fatty acid oxidation with various features including hypoketotic hypoglycemia, recurrent rhabdomyolysis, pigmentary retinopathy, peripheral neuropathy, cardiomyopathy, and arrhythmias. Various stresses trigger metabolic decompensation. Coronavirus disease 2019 (COVID‐19) is a pandemic caused by the RNA virus SARS‐CoV‐2 with diverse presentations ranging from respiratory symptoms to myocarditis. We report a case of a patient with LCHADD who initially presented with typical metabolic decompensation symptoms including nausea, vomiting, and rhabdomyolysis in addition to mild cough, and was found to have COVID‐19. She developed acute respiratory failure and refractory hypotension from severe cardiomyopathy which progressed to multiple organ failure and death. Our case illustrates the need for close monitoring of cardiac function in patients with a long‐chain fatty acid oxidation disorder.
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spelling pubmed-76532422020-11-16 Fatal COVID‐19 infection in a patient with long‐chain 3‐hydroxyacyl‐CoA dehydrogenase deficiency: A case report Wongkittichote, Parith Watson, James R. Leonard, Jennifer M. Toolan, Elizabeth R. Dickson, Patricia I. Grange, Dorothy K. JIMD Rep Case Reports Long‐chain fatty‐acyl CoA dehydrogenase deficiency (LCHADD) is an inborn error of long chain fatty acid oxidation with various features including hypoketotic hypoglycemia, recurrent rhabdomyolysis, pigmentary retinopathy, peripheral neuropathy, cardiomyopathy, and arrhythmias. Various stresses trigger metabolic decompensation. Coronavirus disease 2019 (COVID‐19) is a pandemic caused by the RNA virus SARS‐CoV‐2 with diverse presentations ranging from respiratory symptoms to myocarditis. We report a case of a patient with LCHADD who initially presented with typical metabolic decompensation symptoms including nausea, vomiting, and rhabdomyolysis in addition to mild cough, and was found to have COVID‐19. She developed acute respiratory failure and refractory hypotension from severe cardiomyopathy which progressed to multiple organ failure and death. Our case illustrates the need for close monitoring of cardiac function in patients with a long‐chain fatty acid oxidation disorder. John Wiley & Sons, Inc. 2020-09-10 /pmc/articles/PMC7653242/ /pubmed/33204595 http://dx.doi.org/10.1002/jmd2.12165 Text en © 2020 The Authors. JIMD Reports published by John Wiley & Sons Ltd on behalf of SSIEM. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Reports
Wongkittichote, Parith
Watson, James R.
Leonard, Jennifer M.
Toolan, Elizabeth R.
Dickson, Patricia I.
Grange, Dorothy K.
Fatal COVID‐19 infection in a patient with long‐chain 3‐hydroxyacyl‐CoA dehydrogenase deficiency: A case report
title Fatal COVID‐19 infection in a patient with long‐chain 3‐hydroxyacyl‐CoA dehydrogenase deficiency: A case report
title_full Fatal COVID‐19 infection in a patient with long‐chain 3‐hydroxyacyl‐CoA dehydrogenase deficiency: A case report
title_fullStr Fatal COVID‐19 infection in a patient with long‐chain 3‐hydroxyacyl‐CoA dehydrogenase deficiency: A case report
title_full_unstemmed Fatal COVID‐19 infection in a patient with long‐chain 3‐hydroxyacyl‐CoA dehydrogenase deficiency: A case report
title_short Fatal COVID‐19 infection in a patient with long‐chain 3‐hydroxyacyl‐CoA dehydrogenase deficiency: A case report
title_sort fatal covid‐19 infection in a patient with long‐chain 3‐hydroxyacyl‐coa dehydrogenase deficiency: a case report
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7653242/
https://www.ncbi.nlm.nih.gov/pubmed/33204595
http://dx.doi.org/10.1002/jmd2.12165
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