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Histone H3K79 demethylation by KDM2B facilitates proper DNA replication through PCNA dissociation from chromatin

OBJECTIVES: The level of histone H3 lysine 79 methylation is regulated by the cell cycle and involved in cell proliferation. KDM2B is an H3K79 demethylase. Proliferating cell nuclear antigen (PCNA) is a component of the DNA replication machinery. This study aimed at elucidating a molecular link betw...

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Detalles Bibliográficos
Autores principales: Kang, Joo‐Young, Park, Jin Woo, Hahm, Ja Young, Jung, Hyeonsoo, Seo, Sang‐Beom
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7653264/
https://www.ncbi.nlm.nih.gov/pubmed/33029857
http://dx.doi.org/10.1111/cpr.12920