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The efficiency of insulin production and its content in insulin-expressing model β-cells correlate with their Zn(2+) levels
Insulin is produced and stored inside the pancreatic β-cell secretory granules, where it is assumed to form Zn(2+)-stabilized oligomers. However, the actual storage forms of this hormone and the impact of zinc ions on insulin production in vivo are not known. Our initial X-ray fluorescence experimen...
| Autores principales: | , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7653362/ https://www.ncbi.nlm.nih.gov/pubmed/33081637 http://dx.doi.org/10.1098/rsob.200137 |