Cargando…
Advanced Chronic Kidney Disease is a Strong Predictor of Hypogonadism and is Associated with Decreased Lean Tissue Mass
PURPOSE: In patients with chronic kidney disease (CKD), hypogonadism is more frequent than in the general population and its prevalence ranges between 40% and 60%. The aim of the study was to investigate the prevalence of hypogonadism and its association with kidney function, body composition, infla...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7653405/ https://www.ncbi.nlm.nih.gov/pubmed/33192085 http://dx.doi.org/10.2147/IJNRD.S275554 |
_version_ | 1783607895490822144 |
---|---|
author | Skiba, Ryszard Matyjek, Anna Syryło, Tomasz Niemczyk, Stanisław Rymarz, Aleksandra |
author_facet | Skiba, Ryszard Matyjek, Anna Syryło, Tomasz Niemczyk, Stanisław Rymarz, Aleksandra |
author_sort | Skiba, Ryszard |
collection | PubMed |
description | PURPOSE: In patients with chronic kidney disease (CKD), hypogonadism is more frequent than in the general population and its prevalence ranges between 40% and 60%. The aim of the study was to investigate the prevalence of hypogonadism and its association with kidney function, body composition, inflammatory markers and lipid disorders in patients with CKD. MATERIALS AND METHODS: The study population consisted of 112 men aged ≥40 years in different stages of CKD: 33 participants with eGFR ≥60 mL/min/1.73 m(2), 27 men with eGFR 30–59 mL/min/1.73 m(2), 17 predialysis patients with eGFR <30 mL/min/1.73 m(2), and 35 men on hemodialysis therapy three times a week for more than 3 months (G5D stage). Total testosterone (TT) levels were measured and free testosterone (FT) levels were calculated. Body composition was assessed using bioimpedance spectroscopy (Body Composition Monitor, FMC). Statistical analysis was performed using Statistica version 13.1. RESULTS: CKD stage was a strong predictor of hypogonadism (providing an information value of 0.83). The weight of evidence technique allowed us to differentiate the high-risk group, which was a group of patients with advanced CKD, defined as eGFR <30 mL/min/1.73 m(2). In this group, the likelihood of hypogonadism was 69.23%. Another significant predictor of hypogonadism was lean tissue index (LTI). TT and FT levels were significantly lower in the advanced CKD group in comparison to the control group, whereas prolactin, luteinizing hormone and C-reactive protein levels were significantly higher in the advanced CKD group. The LTI was significantly lower in advanced CKD and was positively correlated with TT and FT. CONCLUSION: Decreased eGFR and decreased LTI are predictors of hypogonadism associated with CKD. The study results suggest that hypogonadism screening should be carried out when eGFR deceases below 30 mL/min/1.73 m(2). |
format | Online Article Text |
id | pubmed-7653405 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-76534052020-11-12 Advanced Chronic Kidney Disease is a Strong Predictor of Hypogonadism and is Associated with Decreased Lean Tissue Mass Skiba, Ryszard Matyjek, Anna Syryło, Tomasz Niemczyk, Stanisław Rymarz, Aleksandra Int J Nephrol Renovasc Dis Original Research PURPOSE: In patients with chronic kidney disease (CKD), hypogonadism is more frequent than in the general population and its prevalence ranges between 40% and 60%. The aim of the study was to investigate the prevalence of hypogonadism and its association with kidney function, body composition, inflammatory markers and lipid disorders in patients with CKD. MATERIALS AND METHODS: The study population consisted of 112 men aged ≥40 years in different stages of CKD: 33 participants with eGFR ≥60 mL/min/1.73 m(2), 27 men with eGFR 30–59 mL/min/1.73 m(2), 17 predialysis patients with eGFR <30 mL/min/1.73 m(2), and 35 men on hemodialysis therapy three times a week for more than 3 months (G5D stage). Total testosterone (TT) levels were measured and free testosterone (FT) levels were calculated. Body composition was assessed using bioimpedance spectroscopy (Body Composition Monitor, FMC). Statistical analysis was performed using Statistica version 13.1. RESULTS: CKD stage was a strong predictor of hypogonadism (providing an information value of 0.83). The weight of evidence technique allowed us to differentiate the high-risk group, which was a group of patients with advanced CKD, defined as eGFR <30 mL/min/1.73 m(2). In this group, the likelihood of hypogonadism was 69.23%. Another significant predictor of hypogonadism was lean tissue index (LTI). TT and FT levels were significantly lower in the advanced CKD group in comparison to the control group, whereas prolactin, luteinizing hormone and C-reactive protein levels were significantly higher in the advanced CKD group. The LTI was significantly lower in advanced CKD and was positively correlated with TT and FT. CONCLUSION: Decreased eGFR and decreased LTI are predictors of hypogonadism associated with CKD. The study results suggest that hypogonadism screening should be carried out when eGFR deceases below 30 mL/min/1.73 m(2). Dove 2020-11-05 /pmc/articles/PMC7653405/ /pubmed/33192085 http://dx.doi.org/10.2147/IJNRD.S275554 Text en © 2020 Skiba et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Original Research Skiba, Ryszard Matyjek, Anna Syryło, Tomasz Niemczyk, Stanisław Rymarz, Aleksandra Advanced Chronic Kidney Disease is a Strong Predictor of Hypogonadism and is Associated with Decreased Lean Tissue Mass |
title | Advanced Chronic Kidney Disease is a Strong Predictor of Hypogonadism and is Associated with Decreased Lean Tissue Mass |
title_full | Advanced Chronic Kidney Disease is a Strong Predictor of Hypogonadism and is Associated with Decreased Lean Tissue Mass |
title_fullStr | Advanced Chronic Kidney Disease is a Strong Predictor of Hypogonadism and is Associated with Decreased Lean Tissue Mass |
title_full_unstemmed | Advanced Chronic Kidney Disease is a Strong Predictor of Hypogonadism and is Associated with Decreased Lean Tissue Mass |
title_short | Advanced Chronic Kidney Disease is a Strong Predictor of Hypogonadism and is Associated with Decreased Lean Tissue Mass |
title_sort | advanced chronic kidney disease is a strong predictor of hypogonadism and is associated with decreased lean tissue mass |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7653405/ https://www.ncbi.nlm.nih.gov/pubmed/33192085 http://dx.doi.org/10.2147/IJNRD.S275554 |
work_keys_str_mv | AT skibaryszard advancedchronickidneydiseaseisastrongpredictorofhypogonadismandisassociatedwithdecreasedleantissuemass AT matyjekanna advancedchronickidneydiseaseisastrongpredictorofhypogonadismandisassociatedwithdecreasedleantissuemass AT syryłotomasz advancedchronickidneydiseaseisastrongpredictorofhypogonadismandisassociatedwithdecreasedleantissuemass AT niemczykstanisław advancedchronickidneydiseaseisastrongpredictorofhypogonadismandisassociatedwithdecreasedleantissuemass AT rymarzaleksandra advancedchronickidneydiseaseisastrongpredictorofhypogonadismandisassociatedwithdecreasedleantissuemass |