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Cyanoamidine Cyclization Approach to Remdesivir’s Nucleobase

[Image: see text] We report an alternative approach to the unnatural nucleobase fragment seen in remdesivir (Veklury). Remdesivir displays broad-spectrum antiviral activity and is currently being evaluated in Phase III clinical trials to treat patients with COVID-19. Our route relies on the formatio...

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Detalles Bibliográficos
Autores principales:	Knapp, Rachel R., Tona, Veronica, Okada, Taku, Sarpong, Richmond, Garg, Neil K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2020
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7653677/ https://www.ncbi.nlm.nih.gov/pubmed/33085486 http://dx.doi.org/10.1021/acs.orglett.0c03052

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