Cargando…

Diabetic phenotype in mouse and humans reduces the number of microglia around β-amyloid plaques

BACKGROUND: Alzheimer’s disease (AD) is the most common neurodegenerative disease and type 2 diabetes (T2D) plays an important role in conferring the risk for AD. Although AD and T2D share common features, the common molecular mechanisms underlying these two diseases remain elusive. METHODS: Mice wi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Natunen, Teemu, Martiskainen, Henna, Marttinen, Mikael, Gabbouj, Sami, Koivisto, Hennariikka, Kemppainen, Susanna, Kaipainen, Satu, Takalo, Mari, Svobodová, Helena, Leppänen, Luukas, Kemiläinen, Benjam, Ryhänen, Simo, Kuulasmaa, Teemu, Rahunen, Eija, Juutinen, Sisko, Mäkinen, Petra, Miettinen, Pasi, Rauramaa, Tuomas, Pihlajamäki, Jussi, Haapasalo, Annakaisa, Leinonen, Ville, Tanila, Heikki, Hiltunen, Mikko
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7653710/ https://www.ncbi.nlm.nih.gov/pubmed/33168021 http://dx.doi.org/10.1186/s13024-020-00415-2

Ejemplares similares

Altered Insulin Signaling in Alzheimer’s Disease Brain – Special Emphasis on PI3K-Akt Pathway
por: Gabbouj, Sami, et al.
Publicado: (2019)

MECP2 Increases the Pro-Inflammatory Response of Microglial Cells and Phosphorylation at Serine 423 Regulates Neuronal Gene Expression upon Neuroinflammation
por: Wittrahm, Rebekka, et al.
Publicado: (2021)

Molecular Mechanisms of Synaptotoxicity and Neuroinflammation in Alzheimer’s Disease
por: Marttinen, Mikael, et al.
Publicado: (2018)

Presynaptic Vesicle Protein SEPTIN5 Regulates the Degradation of APP C-Terminal Fragments and the Levels of Aβ
por: Marttinen, Mikael, et al.
Publicado: (2020)

Decreased plasma C‐reactive protein levels in APOE ε4 allele carriers
por: Martiskainen, Henna, et al.
Publicado: (2018)

Regulation of key proteins in Alzheimer’s disease molecular pathogenesis by ubiquilin-1
por: Takalo, Mari, et al.
Publicado: (2013)

The Alzheimer’s disease-associated protective Plcγ2-P522R variant promotes immune functions
por: Takalo, Mari, et al.
Publicado: (2020)

C9orf72 Proteins Regulate Autophagy and Undergo Autophagosomal or Proteasomal Degradation in a Cell Type-Dependent Manner
por: Leskelä, Stina, et al.
Publicado: (2019)

DHCR24 exerts neuroprotection upon inflammation-induced neuronal death
por: Martiskainen, Henna, et al.
Publicado: (2017)

Effects of NR1H3 Genetic Variation on the Expression of Liver X Receptor α and the Progression of Alzheimer's Disease
por: Natunen, Teemu, et al.
Publicado: (2013)

Astrocytes and Microglia as Potential Contributors to the Pathogenesis of C9orf72 Repeat Expansion-Associated FTLD and ALS
por: Rostalski, Hannah, et al.
Publicado: (2019)

Behavioral testing of mice exposed to intermediate frequency magnetic fields indicates mild memory impairment
por: Kumari, Kajal, et al.
Publicado: (2017)

BV-2 Microglial Cells Overexpressing C9orf72 Hexanucleotide Repeat Expansion Produce DPR Proteins and Show Normal Functionality but No RNA Foci
por: Rostalski, Hannah, et al.
Publicado: (2020)

Organotypic Hippocampal Slice Cultures from Adult Tauopathy Mice and Theragnostic Evaluation of Nanomaterial Phospho-TAU Antibody-Conjugates
por: Kemppainen, Susanna, et al.
Publicado: (2023)

Synaptic dysfunction and septin protein family members in neurodegenerative diseases
por: Marttinen, Mikael, et al.
Publicado: (2015)

iNPH—the mystery resolving
por: Leinonen, Ville, et al.
Publicado: (2021)

Contribution of genetic and dietary insulin resistance to Alzheimer phenotype in APP/PS1 transgenic mice
por: Hiltunen, Mikko, et al.
Publicado: (2012)

l-Type Amino Acid Transporter 1 (LAT1/Lat1)-Utilizing Prodrugs Can Improve the Delivery of Drugs into Neurons, Astrocytes and Microglia
por: Huttunen, Johanna, et al.
Publicado: (2019)

Increased γ-Secretase Activity in Idiopathic Normal Pressure Hydrocephalus Patients with β-Amyloid Pathology
por: Laiterä, Tiina, et al.
Publicado: (2014)

Gene Expression Profile as a Predictor of Seizure Liability
por: Lipponen, Anssi, et al.
Publicado: (2023)

Treatment of Status Epilepticus after Traumatic Brain Injury Using an Antiseizure Drug Combined with a Tissue Recovery Enhancer Revealed by Systems Biology
por: Kajevu, Natallie, et al.
Publicado: (2023)

Genetic Loci Associated with Alzheimer’s Disease and Cerebrospinal Fluid Biomarkers in a Finnish Case-Control Cohort
por: Elias-Sonnenschein, Lyzel S., et al.
Publicado: (2013)

γ-Secretase Components as Predictors of Breast Cancer Outcome
por: Peltonen, Hanna M., et al.
Publicado: (2013)

Activation of the hypoxia response protects mice from amyloid-β accumulation
por: Ollonen, Teemu, et al.
Publicado: (2022)

The Impact of Bdnf Gene Deficiency to the Memory Impairment and Brain Pathology of APPswe/PS1dE9 Mouse Model of Alzheimer’s Disease
por: Rantamäki, Tomi, et al.
Publicado: (2013)

Neighbourhood Ethnic Density, Local Language Skills, and Loneliness among Older Migrants—A Population-Based Study on Russian Speakers in Finland
por: Kemppainen, Laura, et al.
Publicado: (2023)

Patient-derived skin fibroblasts as a model to study frontotemporal lobar degeneration
por: Hoffmann, Dorit, et al.
Publicado: (2022)

Bepridil decreases Aβ and calcium levels in the thalamus after middle cerebral artery occlusion in rats
por: Sarajärvi, Timo, et al.
Publicado: (2012)

Non-Cholesterol Sterol Levels Predict Hyperglycemia and Conversion to Type 2 Diabetes in Finnish Men
por: Cederberg, Henna, et al.
Publicado: (2013)

Health and self-perceived barriers to internet use among older migrants: a population-based study
por: Kouvonen, Anne, et al.
Publicado: (2022)

An intronic variant in the GCKR gene is associated with multiple lipids
por: Fernandes Silva, Lilian, et al.
Publicado: (2019)

Corrigendum: Chronic Pyruvate Supplementation Increases Exploratory Activity and Brain Energy Reserves in Young and Middle-Aged Mice
por: Koivisto, Hennariikka, et al.
Publicado: (2017)

Rationale and Description of Implementation of Regional Collaborative Service Model for Enhancing Psychosocial Wellbeing of Children and Families—Oulu Collective Impact Study
por: Takalo, Tuula, et al.
Publicado: (2022)

Use of complementary and alternative medicine in Europe: Health-related and sociodemographic determinants
por: Kemppainen, Laura M., et al.
Publicado: (2017)

Digital Information Technology Use, Self-Rated Health, and Depression: Population-Based Analysis of a Survey Study on Older Migrants
por: Kouvonen, Anne, et al.
Publicado: (2021)

Detecting Distal Radius Fractures Using a Segmentation-Based Deep Learning Model
por: Anttila, Turkka T., et al.
Publicado: (2022)

Preservation of fatty acid signatures in three vertebrate species after six months of storage at various temperatures
por: Nieminen, Petteri, et al.
Publicado: (2018)

Both Fasting and Glucose-Stimulated Proinsulin Levels Predict Hyperglycemia and Incident Type 2 Diabetes: A Population-Based Study of 9,396 Finnish Men
por: Vangipurapu, Jagadish, et al.
Publicado: (2015)

Chronic Pyruvate Supplementation Increases Exploratory Activity and Brain Energy Reserves in Young and Middle-Aged Mice
por: Koivisto, Hennariikka, et al.
Publicado: (2016)

Medium-Chain Length Fatty Acids Enhance Aβ Degradation by Affecting Insulin-Degrading Enzyme
por: Mett, Janine, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_63tlhfq5ugp87ldmqqcqeg4dqv