Genetic and epigenetic landscape of IDH-wildtype glioblastomas with FGFR3-TACC3 fusions

A subset of glioblastomas (GBMs) harbors potentially druggable oncogenic FGFR3-TACC3 (F3T3) fusions. However, their associated molecular and clinical features are poorly understood. Here we analyze the frequency of F3T3-fusion positivity, its associated genetic and methylation profiles, and its impa...

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Detalles Bibliográficos
Autores principales: Mata, Douglas A., Benhamida, Jamal K., Lin, Andrew L., Vanderbilt, Chad M., Yang, Soo-Ryum, Villafania, Liliana B., Ferguson, Donna C., Jonsson, Philip, Miller, Alexandra M., Tabar, Viviane, Brennan, Cameron W., Moss, Nelson S., Sill, Martin, Benayed, Ryma, Mellinghoff, Ingo K., Rosenblum, Marc K., Arcila, Maria E., Ladanyi, Marc, Bale, Tejus A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7653727/
https://www.ncbi.nlm.nih.gov/pubmed/33168106
http://dx.doi.org/10.1186/s40478-020-01058-6

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