Research and application of single-cell sequencing in tumor heterogeneity and drug resistance of circulating tumor cells

Malignant tumor is a largely harmful disease worldwide. The cure rate of malignant tumors increases with the continuous discovery of anti-tumor drugs and the optimisation of chemotherapy options. However, drug resistance of tumor cells remains a massive obstacle in the treatment of anti-tumor drugs....

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Autores principales: Dai, Zhe, Gu, Xu-yu, Xiang, Shou-yan, Gong, Dan-dan, Man, Chang-feng, Fan, Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7653877/
https://www.ncbi.nlm.nih.gov/pubmed/33292625
http://dx.doi.org/10.1186/s40364-020-00240-1
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author Dai, Zhe
Gu, Xu-yu
Xiang, Shou-yan
Gong, Dan-dan
Man, Chang-feng
Fan, Yu
author_facet Dai, Zhe
Gu, Xu-yu
Xiang, Shou-yan
Gong, Dan-dan
Man, Chang-feng
Fan, Yu
author_sort Dai, Zhe
collection PubMed
description Malignant tumor is a largely harmful disease worldwide. The cure rate of malignant tumors increases with the continuous discovery of anti-tumor drugs and the optimisation of chemotherapy options. However, drug resistance of tumor cells remains a massive obstacle in the treatment of anti-tumor drugs. The heterogeneity of malignant tumors makes studying it further difficult for us. In recent years, using single-cell sequencing technology to study and analyse circulating tumor cells can avoid the interference of tumor heterogeneity and provide a new perspective for us to understand tumor drug resistance.
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spelling pubmed-76538772020-11-10 Research and application of single-cell sequencing in tumor heterogeneity and drug resistance of circulating tumor cells Dai, Zhe Gu, Xu-yu Xiang, Shou-yan Gong, Dan-dan Man, Chang-feng Fan, Yu Biomark Res Review Malignant tumor is a largely harmful disease worldwide. The cure rate of malignant tumors increases with the continuous discovery of anti-tumor drugs and the optimisation of chemotherapy options. However, drug resistance of tumor cells remains a massive obstacle in the treatment of anti-tumor drugs. The heterogeneity of malignant tumors makes studying it further difficult for us. In recent years, using single-cell sequencing technology to study and analyse circulating tumor cells can avoid the interference of tumor heterogeneity and provide a new perspective for us to understand tumor drug resistance. BioMed Central 2020-11-10 /pmc/articles/PMC7653877/ /pubmed/33292625 http://dx.doi.org/10.1186/s40364-020-00240-1 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Dai, Zhe
Gu, Xu-yu
Xiang, Shou-yan
Gong, Dan-dan
Man, Chang-feng
Fan, Yu
Research and application of single-cell sequencing in tumor heterogeneity and drug resistance of circulating tumor cells
title Research and application of single-cell sequencing in tumor heterogeneity and drug resistance of circulating tumor cells
title_full Research and application of single-cell sequencing in tumor heterogeneity and drug resistance of circulating tumor cells
title_fullStr Research and application of single-cell sequencing in tumor heterogeneity and drug resistance of circulating tumor cells
title_full_unstemmed Research and application of single-cell sequencing in tumor heterogeneity and drug resistance of circulating tumor cells
title_short Research and application of single-cell sequencing in tumor heterogeneity and drug resistance of circulating tumor cells
title_sort research and application of single-cell sequencing in tumor heterogeneity and drug resistance of circulating tumor cells
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7653877/
https://www.ncbi.nlm.nih.gov/pubmed/33292625
http://dx.doi.org/10.1186/s40364-020-00240-1
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