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N6-methyladenine modification in noncoding RNAs and its function in cancer

Non-coding RNAs are the main component of the extensive transcription results of the mammalian genome. They are not transcribed into proteins but play critical roles in regulating multiple biological processes and affecting cancer progression. m6A modification is one of the most abundant internal RN...

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Autores principales: Yang, Xinyu, Hu, Xiang, Liu, Jinting, Wang, Ruiqing, Zhang, Chen, Han, Fengjiao, Chen, Yuhong, Ma, Daoxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7653994/
https://www.ncbi.nlm.nih.gov/pubmed/33292652
http://dx.doi.org/10.1186/s40364-020-00244-x
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author Yang, Xinyu
Hu, Xiang
Liu, Jinting
Wang, Ruiqing
Zhang, Chen
Han, Fengjiao
Chen, Yuhong
Ma, Daoxin
author_facet Yang, Xinyu
Hu, Xiang
Liu, Jinting
Wang, Ruiqing
Zhang, Chen
Han, Fengjiao
Chen, Yuhong
Ma, Daoxin
author_sort Yang, Xinyu
collection PubMed
description Non-coding RNAs are the main component of the extensive transcription results of the mammalian genome. They are not transcribed into proteins but play critical roles in regulating multiple biological processes and affecting cancer progression. m6A modification is one of the most abundant internal RNA modification of mammalian cells, and it involves almost all aspects of RNA metabolism. Recent research revealed tight correlations between m6A modification and ncRNAs and indicated the interaction between m6A and ncRNAs act a pivotal part in the development of cancer. The correlation between m6A modification and ncRNAs provides a new perspective for exploring the potential regulatory mechanism of tumor gene expression, and suggest that m6A modification and ncRNAs may be important prognostic markers and therapeutic targets for multiple cancers. In this review, we summarize the potential regulatory mechanisms between m6A methylation and ncRNAs, highlighting how their relationship affects biological functions in cancer.
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spelling pubmed-76539942020-11-10 N6-methyladenine modification in noncoding RNAs and its function in cancer Yang, Xinyu Hu, Xiang Liu, Jinting Wang, Ruiqing Zhang, Chen Han, Fengjiao Chen, Yuhong Ma, Daoxin Biomark Res Review Non-coding RNAs are the main component of the extensive transcription results of the mammalian genome. They are not transcribed into proteins but play critical roles in regulating multiple biological processes and affecting cancer progression. m6A modification is one of the most abundant internal RNA modification of mammalian cells, and it involves almost all aspects of RNA metabolism. Recent research revealed tight correlations between m6A modification and ncRNAs and indicated the interaction between m6A and ncRNAs act a pivotal part in the development of cancer. The correlation between m6A modification and ncRNAs provides a new perspective for exploring the potential regulatory mechanism of tumor gene expression, and suggest that m6A modification and ncRNAs may be important prognostic markers and therapeutic targets for multiple cancers. In this review, we summarize the potential regulatory mechanisms between m6A methylation and ncRNAs, highlighting how their relationship affects biological functions in cancer. BioMed Central 2020-11-10 /pmc/articles/PMC7653994/ /pubmed/33292652 http://dx.doi.org/10.1186/s40364-020-00244-x Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Yang, Xinyu
Hu, Xiang
Liu, Jinting
Wang, Ruiqing
Zhang, Chen
Han, Fengjiao
Chen, Yuhong
Ma, Daoxin
N6-methyladenine modification in noncoding RNAs and its function in cancer
title N6-methyladenine modification in noncoding RNAs and its function in cancer
title_full N6-methyladenine modification in noncoding RNAs and its function in cancer
title_fullStr N6-methyladenine modification in noncoding RNAs and its function in cancer
title_full_unstemmed N6-methyladenine modification in noncoding RNAs and its function in cancer
title_short N6-methyladenine modification in noncoding RNAs and its function in cancer
title_sort n6-methyladenine modification in noncoding rnas and its function in cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7653994/
https://www.ncbi.nlm.nih.gov/pubmed/33292652
http://dx.doi.org/10.1186/s40364-020-00244-x
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