Morphine leads to global genome changes in H3K27me3 levels via a Polycomb Repressive Complex 2 (PRC2) self-regulatory mechanism in mESCs

BACKGROUND: Environmentally induced epigenetic changes can lead to health problems or disease, but the mechanisms involved remain unclear. Morphine can pass through the placental barrier leading to abnormal embryo development. However, the mechanism by which morphine causes these effects and how the...

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Detalles Bibliográficos
Autores principales: Muñoa-Hoyos, Iraia, Halsall, John A., Araolaza, Manu, Ward, Carl, Garcia, Idoia, Urizar-Arenaza, Itziar, Gianzo, Marta, Garcia, Paloma, Turner, Bryan, Subirán, Nerea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7654014/
https://www.ncbi.nlm.nih.gov/pubmed/33168052
http://dx.doi.org/10.1186/s13148-020-00955-w

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