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The Enzymatic Activity of the nsp14 Exoribonuclease Is Critical for Replication of MERS-CoV and SARS-CoV-2

Coronaviruses (CoVs) stand out for their large RNA genome and complex RNA-synthesizing machinery comprising 16 nonstructural proteins (nsps). The bifunctional nsp14 contains 3′-to-5′ exoribonuclease (ExoN) and guanine-N7-methyltransferase (N7-MTase) domains. While the latter presumably supports mRNA...

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Detalles Bibliográficos
Autores principales:	Ogando, Natacha S., Zevenhoven-Dobbe, Jessika C., van der Meer, Yvonne, Bredenbeek, Peter J., Posthuma, Clara C., Snijder, Eric J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2020
Materias:	Genome Replication and Regulation of Viral Gene Expression
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7654266/ https://www.ncbi.nlm.nih.gov/pubmed/32938769 http://dx.doi.org/10.1128/JVI.01246-20

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