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A model of COVID-19 propagation based on a gamma subordinated negative binomial branching process

We build a parsimonious Crump-Mode-Jagers continuous time branching process of COVID-19 propagation based on a negative binomial process subordinated by a gamma subordinator. By focusing on the stochastic nature of the process in small populations, our model provides decision making insight into mit...

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Detalles Bibliográficos
Autores principales: Levesque, Jérôme, Maybury, David W., Shaw, R.H.A. David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Ltd. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7654309/
https://www.ncbi.nlm.nih.gov/pubmed/33186594
http://dx.doi.org/10.1016/j.jtbi.2020.110536
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author Levesque, Jérôme
Maybury, David W.
Shaw, R.H.A. David
author_facet Levesque, Jérôme
Maybury, David W.
Shaw, R.H.A. David
author_sort Levesque, Jérôme
collection PubMed
description We build a parsimonious Crump-Mode-Jagers continuous time branching process of COVID-19 propagation based on a negative binomial process subordinated by a gamma subordinator. By focusing on the stochastic nature of the process in small populations, our model provides decision making insight into mitigation strategies as an outbreak begins. Our model accommodates contact tracing and isolation, allowing for comparisons between different types of intervention. We emphasize a physical interpretation of the disease propagation throughout which affords analytical results for comparison to simulations. Our model provides a basis for decision makers to understand the likely trade-offs and consequences between alternative outbreak mitigation strategies particularly in office environments and confined work-spaces. Combining the asymptotic limit of our model with Bayesian hierarchical techniques, we provide US county level inferences for the reproduction number from cumulative case count data over July and August of this year.
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spelling pubmed-76543092020-11-12 A model of COVID-19 propagation based on a gamma subordinated negative binomial branching process Levesque, Jérôme Maybury, David W. Shaw, R.H.A. David J Theor Biol Article We build a parsimonious Crump-Mode-Jagers continuous time branching process of COVID-19 propagation based on a negative binomial process subordinated by a gamma subordinator. By focusing on the stochastic nature of the process in small populations, our model provides decision making insight into mitigation strategies as an outbreak begins. Our model accommodates contact tracing and isolation, allowing for comparisons between different types of intervention. We emphasize a physical interpretation of the disease propagation throughout which affords analytical results for comparison to simulations. Our model provides a basis for decision makers to understand the likely trade-offs and consequences between alternative outbreak mitigation strategies particularly in office environments and confined work-spaces. Combining the asymptotic limit of our model with Bayesian hierarchical techniques, we provide US county level inferences for the reproduction number from cumulative case count data over July and August of this year. Published by Elsevier Ltd. 2021-03-07 2020-11-10 /pmc/articles/PMC7654309/ /pubmed/33186594 http://dx.doi.org/10.1016/j.jtbi.2020.110536 Text en Crown Copyright © 2020 Published by Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Levesque, Jérôme
Maybury, David W.
Shaw, R.H.A. David
A model of COVID-19 propagation based on a gamma subordinated negative binomial branching process
title A model of COVID-19 propagation based on a gamma subordinated negative binomial branching process
title_full A model of COVID-19 propagation based on a gamma subordinated negative binomial branching process
title_fullStr A model of COVID-19 propagation based on a gamma subordinated negative binomial branching process
title_full_unstemmed A model of COVID-19 propagation based on a gamma subordinated negative binomial branching process
title_short A model of COVID-19 propagation based on a gamma subordinated negative binomial branching process
title_sort model of covid-19 propagation based on a gamma subordinated negative binomial branching process
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7654309/
https://www.ncbi.nlm.nih.gov/pubmed/33186594
http://dx.doi.org/10.1016/j.jtbi.2020.110536
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