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Enabling protein-hosted organocatalytic transformations
In this review, the development of organocatalytic artificial enzymes will be discussed. This area of protein engineering research has underlying importance, as it enhances the biocompatibility of organocatalysis for applications in chemical and synthetic biology research whilst expanding the cataly...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7654312/ https://www.ncbi.nlm.nih.gov/pubmed/33184588 http://dx.doi.org/10.1039/d0ra01526a |
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author | Nödling, Alexander R. Santi, Nicolò Williams, Thomas L. Tsai, Yu-Hsuan Luk, Louis Y. P. |
author_facet | Nödling, Alexander R. Santi, Nicolò Williams, Thomas L. Tsai, Yu-Hsuan Luk, Louis Y. P. |
author_sort | Nödling, Alexander R. |
collection | PubMed |
description | In this review, the development of organocatalytic artificial enzymes will be discussed. This area of protein engineering research has underlying importance, as it enhances the biocompatibility of organocatalysis for applications in chemical and synthetic biology research whilst expanding the catalytic repertoire of enzymes. The approaches towards the preparation of organocatalytic artificial enzymes, techniques used to improve their performance (selectivity and reactivity) as well as examples of their applications are presented. Challenges and opportunities are also discussed. |
format | Online Article Text |
id | pubmed-7654312 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | The Royal Society of Chemistry |
record_format | MEDLINE/PubMed |
spelling | pubmed-76543122020-11-10 Enabling protein-hosted organocatalytic transformations Nödling, Alexander R. Santi, Nicolò Williams, Thomas L. Tsai, Yu-Hsuan Luk, Louis Y. P. RSC Adv Chemistry In this review, the development of organocatalytic artificial enzymes will be discussed. This area of protein engineering research has underlying importance, as it enhances the biocompatibility of organocatalysis for applications in chemical and synthetic biology research whilst expanding the catalytic repertoire of enzymes. The approaches towards the preparation of organocatalytic artificial enzymes, techniques used to improve their performance (selectivity and reactivity) as well as examples of their applications are presented. Challenges and opportunities are also discussed. The Royal Society of Chemistry 2020-04-23 /pmc/articles/PMC7654312/ /pubmed/33184588 http://dx.doi.org/10.1039/d0ra01526a Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/ |
spellingShingle | Chemistry Nödling, Alexander R. Santi, Nicolò Williams, Thomas L. Tsai, Yu-Hsuan Luk, Louis Y. P. Enabling protein-hosted organocatalytic transformations |
title | Enabling protein-hosted organocatalytic transformations |
title_full | Enabling protein-hosted organocatalytic transformations |
title_fullStr | Enabling protein-hosted organocatalytic transformations |
title_full_unstemmed | Enabling protein-hosted organocatalytic transformations |
title_short | Enabling protein-hosted organocatalytic transformations |
title_sort | enabling protein-hosted organocatalytic transformations |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7654312/ https://www.ncbi.nlm.nih.gov/pubmed/33184588 http://dx.doi.org/10.1039/d0ra01526a |
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