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Epicardial adipose tissue, inflammatory biomarkers and COVID-19: Is there a possible relationship?

BACKGROUND & AIMS: Adipose tissue is a biologically active organ with pro-immunogenic properties. We aimed to evaluate the prognostic value of epicardial adipose tissue (EAT) in COVID-19 and its correlation with other inflammatory biomarkers. MATERIAL AND METHODS: One-hundred patients with COVID...

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Autores principales: Abrishami, Alireza, Eslami, Vahid, Baharvand, Zahra, Khalili, Nastaran, Saghamanesh, Somayeh, Zarei, Ehsan, Sanei-Taheri, Morteza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7654386/
https://www.ncbi.nlm.nih.gov/pubmed/33208293
http://dx.doi.org/10.1016/j.intimp.2020.107174
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author Abrishami, Alireza
Eslami, Vahid
Baharvand, Zahra
Khalili, Nastaran
Saghamanesh, Somayeh
Zarei, Ehsan
Sanei-Taheri, Morteza
author_facet Abrishami, Alireza
Eslami, Vahid
Baharvand, Zahra
Khalili, Nastaran
Saghamanesh, Somayeh
Zarei, Ehsan
Sanei-Taheri, Morteza
author_sort Abrishami, Alireza
collection PubMed
description BACKGROUND & AIMS: Adipose tissue is a biologically active organ with pro-immunogenic properties. We aimed to evaluate the prognostic value of epicardial adipose tissue (EAT) in COVID-19 and its correlation with other inflammatory biomarkers. MATERIAL AND METHODS: One-hundred patients with COVID-19 were enrolled. C-reactive protein (CRP), lactate dehydrogenase (LDH), neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-CRP ratio (LCR), and platelet-to-lymphocyte ratio (PLR) were evaluated on admission. EAT volume and density were measured by computed tomography. Patients were followed until death or discharge. Univariate and multivariate analysis was performed and ROC curve analysis was used to assess the ability of inflammatory markers in predicting survival. The relationship between EAT and other inflammatory markers was also investigated. RESULTS: The mean ± SD age of patients was 55.5 ± 15.2 years old; 68% were male. Univariate analysis revealed that increased lung involvement, blood urea nitrogen, LDH and NLR, and decreased platelet count were significantly associated with death. After adjustment, LDH was independently predictive of death (OR = 1.013, p-value = 0.03). Among inflammatory markers, LCR had the best ability for predicting survival with 79.7% sensitivity and 64.3% specificity at an optimal cut-off value of 20.8 (AUC = 0.744, 95% CI = 0.612–0.876, p-value = 0.004). EAT volume demonstrated positive correlation with NLR and PLR (p = 0.001 and 0.01), and a negative correlation with LCR (p = 0.02). EAT density was significantly different between decedents and survivors (p = 0.008). CONCLUSION: Routine laboratory tests that represent status of inflammation can be used as cost-effective prognostic markers of COVID-19. Also, the significant association between EAT volume and other inflammatory biomarkers might explain the more severe disease in obese patients.
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spelling pubmed-76543862020-11-12 Epicardial adipose tissue, inflammatory biomarkers and COVID-19: Is there a possible relationship? Abrishami, Alireza Eslami, Vahid Baharvand, Zahra Khalili, Nastaran Saghamanesh, Somayeh Zarei, Ehsan Sanei-Taheri, Morteza Int Immunopharmacol Article BACKGROUND & AIMS: Adipose tissue is a biologically active organ with pro-immunogenic properties. We aimed to evaluate the prognostic value of epicardial adipose tissue (EAT) in COVID-19 and its correlation with other inflammatory biomarkers. MATERIAL AND METHODS: One-hundred patients with COVID-19 were enrolled. C-reactive protein (CRP), lactate dehydrogenase (LDH), neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-CRP ratio (LCR), and platelet-to-lymphocyte ratio (PLR) were evaluated on admission. EAT volume and density were measured by computed tomography. Patients were followed until death or discharge. Univariate and multivariate analysis was performed and ROC curve analysis was used to assess the ability of inflammatory markers in predicting survival. The relationship between EAT and other inflammatory markers was also investigated. RESULTS: The mean ± SD age of patients was 55.5 ± 15.2 years old; 68% were male. Univariate analysis revealed that increased lung involvement, blood urea nitrogen, LDH and NLR, and decreased platelet count were significantly associated with death. After adjustment, LDH was independently predictive of death (OR = 1.013, p-value = 0.03). Among inflammatory markers, LCR had the best ability for predicting survival with 79.7% sensitivity and 64.3% specificity at an optimal cut-off value of 20.8 (AUC = 0.744, 95% CI = 0.612–0.876, p-value = 0.004). EAT volume demonstrated positive correlation with NLR and PLR (p = 0.001 and 0.01), and a negative correlation with LCR (p = 0.02). EAT density was significantly different between decedents and survivors (p = 0.008). CONCLUSION: Routine laboratory tests that represent status of inflammation can be used as cost-effective prognostic markers of COVID-19. Also, the significant association between EAT volume and other inflammatory biomarkers might explain the more severe disease in obese patients. Elsevier B.V. 2021-01 2020-11-10 /pmc/articles/PMC7654386/ /pubmed/33208293 http://dx.doi.org/10.1016/j.intimp.2020.107174 Text en © 2020 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Abrishami, Alireza
Eslami, Vahid
Baharvand, Zahra
Khalili, Nastaran
Saghamanesh, Somayeh
Zarei, Ehsan
Sanei-Taheri, Morteza
Epicardial adipose tissue, inflammatory biomarkers and COVID-19: Is there a possible relationship?
title Epicardial adipose tissue, inflammatory biomarkers and COVID-19: Is there a possible relationship?
title_full Epicardial adipose tissue, inflammatory biomarkers and COVID-19: Is there a possible relationship?
title_fullStr Epicardial adipose tissue, inflammatory biomarkers and COVID-19: Is there a possible relationship?
title_full_unstemmed Epicardial adipose tissue, inflammatory biomarkers and COVID-19: Is there a possible relationship?
title_short Epicardial adipose tissue, inflammatory biomarkers and COVID-19: Is there a possible relationship?
title_sort epicardial adipose tissue, inflammatory biomarkers and covid-19: is there a possible relationship?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7654386/
https://www.ncbi.nlm.nih.gov/pubmed/33208293
http://dx.doi.org/10.1016/j.intimp.2020.107174
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