Clinical Profile of COVID-19 in Children and Research Progress on Angiotensin-converting Enzyme 2: A Mini-review

The cases of coronavirus disease 2019 in children have been increasing with the ongoing pandemic. The finding suggests children have mild symptoms and a short course of the disease. Angiotensinconverting enzyme-2 mediates entry of the virus into the cell, the combination of virus and ACE2 leads to a...

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Detalles Bibliográficos
Autores principales: Gao, Qian, JingLiu, Mu, Zhilong, Yan, Xianpeng, Shah, Jay Narayan, Jiao, Fuyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Journal of the Nepal Medical Association 2020
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7654480/
https://www.ncbi.nlm.nih.gov/pubmed/34504360
http://dx.doi.org/10.31729/jnma.5436
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author Gao, Qian
JingLiu,
Mu, Zhilong
Yan, Xianpeng
Shah, Jay Narayan
Jiao, Fuyong
author_facet Gao, Qian
JingLiu,
Mu, Zhilong
Yan, Xianpeng
Shah, Jay Narayan
Jiao, Fuyong
author_sort Gao, Qian
collection PubMed
description The cases of coronavirus disease 2019 in children have been increasing with the ongoing pandemic. The finding suggests children have mild symptoms and a short course of the disease. Angiotensinconverting enzyme-2 mediates entry of the virus into the cell, the combination of virus and ACE2 leads to an increase in activity of angiotensin II, resulting in acute injury to lungs, myocardium and other organs. The infection causes down-regulation of ACE2 expression. The ACE2 plays an important role in the infection progression and clinical characteristics of COVID-19. Works on ACE2 and virus spike protein have future prospects of strategic information on prevention, management as well as vaccine development.
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spelling pubmed-76544802020-11-30 Clinical Profile of COVID-19 in Children and Research Progress on Angiotensin-converting Enzyme 2: A Mini-review Gao, Qian JingLiu, Mu, Zhilong Yan, Xianpeng Shah, Jay Narayan Jiao, Fuyong JNMA J Nepal Med Assoc Review Article The cases of coronavirus disease 2019 in children have been increasing with the ongoing pandemic. The finding suggests children have mild symptoms and a short course of the disease. Angiotensinconverting enzyme-2 mediates entry of the virus into the cell, the combination of virus and ACE2 leads to an increase in activity of angiotensin II, resulting in acute injury to lungs, myocardium and other organs. The infection causes down-regulation of ACE2 expression. The ACE2 plays an important role in the infection progression and clinical characteristics of COVID-19. Works on ACE2 and virus spike protein have future prospects of strategic information on prevention, management as well as vaccine development. Journal of the Nepal Medical Association 2020-10 2020-10-31 /pmc/articles/PMC7654480/ /pubmed/34504360 http://dx.doi.org/10.31729/jnma.5436 Text en © The Author(s) 2018. http://creativecommons.org/licenses/by/4.0/ This is an Open-Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Gao, Qian
JingLiu,
Mu, Zhilong
Yan, Xianpeng
Shah, Jay Narayan
Jiao, Fuyong
Clinical Profile of COVID-19 in Children and Research Progress on Angiotensin-converting Enzyme 2: A Mini-review
title Clinical Profile of COVID-19 in Children and Research Progress on Angiotensin-converting Enzyme 2: A Mini-review
title_full Clinical Profile of COVID-19 in Children and Research Progress on Angiotensin-converting Enzyme 2: A Mini-review
title_fullStr Clinical Profile of COVID-19 in Children and Research Progress on Angiotensin-converting Enzyme 2: A Mini-review
title_full_unstemmed Clinical Profile of COVID-19 in Children and Research Progress on Angiotensin-converting Enzyme 2: A Mini-review
title_short Clinical Profile of COVID-19 in Children and Research Progress on Angiotensin-converting Enzyme 2: A Mini-review
title_sort clinical profile of covid-19 in children and research progress on angiotensin-converting enzyme 2: a mini-review
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7654480/
https://www.ncbi.nlm.nih.gov/pubmed/34504360
http://dx.doi.org/10.31729/jnma.5436
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